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Proceedings Paper

Raman spectroscopy of bio fluids: an exploratory study for oral cancer detection
Author(s): Elumalai Brindha; Ramu Rajasekaran; Prakasarao Aruna; Dornadula Koteeswaran; Singaravelu Ganesan
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Paper Abstract

ion for various disease diagnosis including cancers. Oral cancer is one of the most common cancers in India and it accounts for one third of the global oral cancer burden. Raman spectroscopy of tissues has gained much attention in the diagnostic oncology, as it provides unique spectral signature corresponding to metabolic alterations under different pathological conditions and micro-environment. Based on these, several studies have been reported on the use of Raman spectroscopy in the discrimination of diseased conditions from their normal counterpart at cellular and tissue level but only limited studies were available on bio-fluids. Recently, optical characterization of bio-fluids has also geared up for biomarker identification in the disease diagnosis. In this context, an attempt was made to study the metabolic variations in the blood, urine and saliva of oral cancer patients and normal subjects using Raman spectroscopy. Principal Component based Linear Discriminant Analysis (PC-LDA) followed by Leave-One-Out Cross-Validation (LOOCV) was employed to find the statistical significance of the present technique in discriminating the malignant conditions from normal subjects.

Paper Details

Date Published: 7 March 2016
PDF: 6 pages
Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 97031T (7 March 2016); doi: 10.1117/12.2212684
Show Author Affiliations
Elumalai Brindha, Anna Univ., Chennai (India)
Ramu Rajasekaran, Anna Univ., Chennai (India)
Prakasarao Aruna, Anna Univ., Chennai (India)
Dornadula Koteeswaran, Meenakshi Univ. (India)
Singaravelu Ganesan, Anna Univ., Chennai (India)


Published in SPIE Proceedings Vol. 9703:
Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos, Editor(s)

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