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Proceedings Paper

Surface enhanced Raman spectroscopy as a point-of-care diagnostic for infection in wound effluent
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Paper Abstract

In military medicine, one of the challenges in dealing with large combat-related injuries is the prevalence of bacterial infection, including multidrug resistant organisms. This can prolong the wound healing process and lead to wound dehiscence. Current methods of identifying bacterial infection rely on culturing microbes from patient material and performing biochemical tests, which together can take 2-3 days to complete. Surface Enhanced Raman Spectroscopy (SERS) is a powerful vibrational spectroscopy technique that allows for highly sensitive structural detection of analytes adsorbed onto specially prepared metal surfaces. In the past, we have been able to discriminate between bacterial isolates grown on solid culture media using standard Raman spectroscopic methods. Here, SERS is utilized to assess the presence of bacteria in wound effluent samples taken directly from patients. To our knowledge, this is the first attempt for the application of SERS directly to wound effluent. The utilization of SERS as a point-of-care diagnostic tool would enable physicians to determine course of treatment and drug administration in a matter of hours.

Paper Details

Date Published: 4 March 2016
PDF: 8 pages
Proc. SPIE 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 97150B (4 March 2016); doi: 10.1117/12.2212667
Show Author Affiliations
Meron Ghebremedhin, Naval Medical Research Ctr. (United States)
Henry M. Jackson Foundation for the Advancement of Military Medicine (United States)
Shubha Yesupriya, Naval Medical Research Ctr. (United States)
The Geneva Foundation (United States)
Nicole J. Crane, Naval Medical Research Ctr. (United States)
Uniformed Services Univ. of Health Sciences (United States)
Henry M. Jackson Foundation for the Advancement of Military Medicine (United States)


Published in SPIE Proceedings Vol. 9715:
Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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