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Proceedings Paper

Fluorescence anisotropy characterization of urine in the diagnosis of cancer
Author(s): Ramu Rajasekaran; Elumalai Brindha; Shanmugam Sivabalan; Prakasa Rao Aruna; Dornadula Koteeswaran; Singaravelu Ganesan
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Paper Abstract

Cervical cancer is considered as the second most commonly occurring malignancy among women, next to breast cancer. It is well known that most of the cancer patients diagnosed with advanced stages and there is a pressing need for improved methods to detect cancer at its initial stages. Many techniques have been adopted for the diagnosis of cervical cancer. Among these, fluorescence polarization spectroscopy is a complementary technique of fluorescence spectroscopy which helps us to elucidate the spectral characteristics which highly depend on pH, viscosity and local environment. Since urine has many metabolites and the measurement of native fluorescence of urine, in principle, able to provide an indication of a number of health conditions, attempts were made to study fluorescence anisotropic characterization of the human urine of cervical cancer patients and normal subjects. Significant differences were observed between the anisotropic and polarization values of cancer subjects and normal subjects.

Paper Details

Date Published: 7 March 2016
PDF: 6 pages
Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 97031P (7 March 2016); doi: 10.1117/12.2212618
Show Author Affiliations
Ramu Rajasekaran, Anna Univ., Chennai (India)
Elumalai Brindha, Anna Univ., Chennai (India)
Shanmugam Sivabalan, Anna Univ., Chennai (India)
Prakasa Rao Aruna, Anna Univ., Chennai (India)
Dornadula Koteeswaran, Meenakshi Ammal Dental College and Hospital (India)
Singaravelu Ganesan, Anna Univ., Chennai (India)

Published in SPIE Proceedings Vol. 9703:
Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos, Editor(s)

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