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Proceedings Paper

Optogenetic stimulation of myelination (Conference Presentation)
Author(s): In Hong Yang; Hae Ung Lee; Nitish V. Thakor
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Paper Abstract

Myelination is governed by axon-glia interaction which is modulated by neural activity. Currently, the effects of subcellular activation of neurons which induce neural activity upon myelination are not well understood. To identify if subcellular neuronal stimulation can enhance myelination, we developed a novel system for focal stimulation of neural activity with optogenetic in a compartmentalized microfluidic platform. In our systems, stimulation for neurons in restricted subcellular parts, such as cell bodies and axons promoted oligodendrocyte differentiation and the myelination of axons the just as much as whole cell activation of neurons did. The number of premature O4 positive oligodendrocytes was reduced and the numbers of mature and myelin basic protein-positive oligodendrocytes was increased both by subcellular optogenetic stimulation.

Paper Details

Date Published: 26 April 2016
PDF: 1 pages
Proc. SPIE 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 96902A (26 April 2016); doi: 10.1117/12.2212607
Show Author Affiliations
In Hong Yang, Johns Hopkins Univ. (United States)
National Univ. of Singapore (Singapore)
Hae Ung Lee, National Univ. of Singapore (Singapore)
Nitish V. Thakor, National Univ. of Singapore (Singapore)
Johns Hopkins Univ. (United States)


Published in SPIE Proceedings Vol. 9690:
Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation
Steen J. Madsen; Victor X. D. Yang; E. Duco Jansen; Qingming Luo; Samarendra K. Mohanty; Nitish V. Thakor, Editor(s)

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