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Proceedings Paper

Membrane-targeting liquid crystal nanoparticles (LCNPs) for drug delivery
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Paper Abstract

In addition to maintaining the structural integrity of the cell, the plasma membrane regulates multiple important cellular processes, such as endocytosis and trafficking, apoptotic pathways and drug transport. The modulation or tracking of such cellular processes by means of controlled delivery of drugs or imaging agents via nanoscale delivery systems is very attractive. Nanoparticle-mediated delivery systems that mediate long-term residence (e.g., days) and controlled release of the cargoes in the plasma membrane while simultaneously not interfering with regular cellular physiology would be ideal for this purpose. Our laboratory has developed a plasma membrane-targeted liquid crystal nanoparticle (LCNP) formulation that can be loaded with dyes or drugs which can be slowly released from the particle over time. Here we highlight the utility of these nanopreparations for membrane delivery and imaging.

Paper Details

Date Published: 22 April 2016
PDF: 6 pages
Proc. SPIE 9722, Colloidal Nanoparticles for Biomedical Applications XI, 972215 (22 April 2016); doi: 10.1117/12.2212529
Show Author Affiliations
Okhil K. Nag, U.S. Naval Research Lab. (United States)
Jawad Naciri, U.S. Naval Research Lab. (United States)
Christopher M. Spillmann, U.S. Naval Research Lab. (United States)
James B. Delehanty, U.S. Naval Research Lab. (United States)

Published in SPIE Proceedings Vol. 9722:
Colloidal Nanoparticles for Biomedical Applications XI
Wolfgang J. Parak; Marek Osinski; Xing-Jie Liang, Editor(s)

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