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Proceedings Paper

One-step fabrication of triple-layered microcapsules by a tri-axial flow focusing device for microencapsulation of soluble drugs and imaging agents
Author(s): Shuai Yuan; Qiang Wu; Fan Lei; Guangbin Li; Ting Si; Ronald X. Xu
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Paper Abstract

In this work, the microencapsulation of water-soluble drug (doxorubicin, Dox) and imaging agent (perfluorocarbon, PFC) is performed by a novel liquid driven tri-axial flow focusing (LDTFF) device. The formation of stable triple-layered cone-jet mode can be observed in the simple well-assembled LDTFF device, providing an easy approach to fabricate mono-disperse triple-layered microcapsules with high encapsulation efficiency, high throughput and low cost in just one step. The fluorescence images show that the microcapsules have a satisfactory core-shell structure. The SEM micrographs show spherical and smooth surface views of the triple-layered microcapsules after being stirred 72h to remove the organic solvent totally. The results of thermo-responsive release experiments of the produced triple-layered microcapsules show these multifunctional capsules can be well stimulated when the environment temperature is beyond 55 degree centigrade. In a word, this novel approach has a great potential in applications such as drug delivery and image-guided therapy.

Paper Details

Date Published: 6 April 2016
PDF: 11 pages
Proc. SPIE 9711, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, 97111F (6 April 2016); doi: 10.1117/12.2212506
Show Author Affiliations
Shuai Yuan, Univ. of Science and Technology of China (China)
The Ohio State Univ. (United States)
Qiang Wu, Univ. of Science and Technology of China (China)
Fan Lei, Univ. of Science and Technology of China (China)
Guangbin Li, Univ.of Science and Technology of China (China)
Ting Si, Univ. of Science and Technology of China (China)
The Ohio State Univ. (United States)
Ronald X. Xu, Univ. of Science and Technology of China (China)
The Ohio State Univ. (United States)


Published in SPIE Proceedings Vol. 9711:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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