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Proceedings Paper

Preliminary studies of fluorescence image-guided photothermal therapy of human oesophageal adenocarcinoma in vivo using multifunctional gold nanorods
Author(s): Elham Nabavi; Mohan Singh; Yu Zhou; Maria Elena Gallina; Hailin Zhao; Daqing Ma; Anthony Cass; George Hanna; Daniel S. Elson
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Paper Abstract

We present a preliminary in vivo study of fluorescence imaging and photothermal therapy (PTT) of human oesophageal adenocarcinoma using multi-functionalised gold nanorods (GNRs). After establishing tumour xenograft in mouse functionalised GNRs were administrated intravenously (IV). Fluorescence imaging was performed to detect the tumour area. The intensity of the fluorescence signal varied significantly across the tumour site and surrounding tissues. PTT was then performed using a 808 nm continuous wave diode laser to irradiate the tumour for 3 minutes, inducing a temperature rise of ~44°C, which photothermally ablated the tumour.

Paper Details

Date Published: 1 March 2016
PDF: 4 pages
Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 96940G (1 March 2016); doi: 10.1117/12.2212337
Show Author Affiliations
Elham Nabavi, Imperial College London (United Kingdom)
Mohan Singh, Imperial College London (United Kingdom)
Yu Zhou, Imperial College London (United Kingdom)
Maria Elena Gallina, Imperial College London (United Kingdom)
Hailin Zhao, Imperial College London (United Kingdom)
Daqing Ma, Imperial College London (United Kingdom)
Anthony Cass, Imperial College London (United Kingdom)
George Hanna, Imperial College London (United Kingdom)
Daniel S. Elson, Imperial College London (United Kingdom)


Published in SPIE Proceedings Vol. 9694:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV
David H. Kessel; Tayyaba Hasan, Editor(s)

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