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Proceedings Paper

Novel organosilicon phantoms as testing material for photoacoustic imaging
Author(s): Cinzia Avigo; Paolo Armanetti; Cecilia Masciullo; Nicole Di Lascio; Lucia Cavigli; Fulvio Ratto; Roberto Pini; Marco Cecchini; Claudia Kusmic; Francesco Faita; Luca Menichetti
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Paper Abstract

The contrast in photoacoustic (PA) imaging depends on the mechanical and elastic properties of the tissue, as well as on his optical absorption and scatter properties. Thanks to these futures, this novel modality could offer additional specificity compared to conventional ultrasound techniques, being able to reveal the signal of absorbing materials and chomophores, e.g. endogenous molecules like haemoglobin or specific near infrared dyes or plasmonic contrast agents. The development of semi-quantitative protocols for the assessment of the contrast enhancement, is one of the key aspect of the ongoing research, that could open new routes to the use of PA imaging for a variety of applications in preclinical research of cancer and cardiovascular diseases. In this work, we designed and tested a tissue mimicking polydimethylsiloxane (PDMS) phantom for photoacoustic applications, with tailored biomechanical/optical and geometrical properties. In order to modulate the light fluence and penetration, that remains one of the major challenge for this technique, we added titanium dioxide and black ink, rendering the optical absorption and scattering coefficients similar to those of biological tissues. The PDMS phantom can become a particularly promising tool in the field of photoacoustics for the evaluation of the performance of a PA system and as a model of the structure of vascularized soft tissues.

Paper Details

Date Published: 18 March 2016
PDF: 8 pages
Proc. SPIE 9700, Design and Quality for Biomedical Technologies IX, 97000I (18 March 2016); doi: 10.1117/12.2212306
Show Author Affiliations
Cinzia Avigo, Institute of Clinical Physiology, CNR (Italy)
Paolo Armanetti, Univ. of Pisa (Italy)
Cecilia Masciullo, Instituto Nanoscienze, CNR (Italy)
Scuola Normale Superiore (Italy)
Nicole Di Lascio, Institute of Clinical Physiology, CNR (Italy)
Scuola Superiore Sant'Anna (Italy)
Lucia Cavigli, Institute of Applied Physics "N. Carrara," CNR (Italy)
Fulvio Ratto, Institute of Applied Physics "N. Carrara," CNR (Italy)
Roberto Pini, Institute of Applied Physics "N. Carrara," CNR (Italy)
Marco Cecchini, Istituto Nanoscienze, CNR (Italy)
Scuola Normale Superiore (Italy)
Claudia Kusmic, Institute of Clinical Physiology, CNR (Italy)
Francesco Faita, Institute of Clinical Physiology, CNR (Italy)
Luca Menichetti, Institute of Clinical Physiology, CNR (Italy)
Fondazione CNR (Italy)


Published in SPIE Proceedings Vol. 9700:
Design and Quality for Biomedical Technologies IX
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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