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Proceedings Paper

Blood flow changes after unilateral carotid artery ligation monitored by optical coherence tomography
Author(s): Yushu Ma; Chengbo Liang; Yanyan Suo; Yuqian Zhao; Yi Wang; Tao Xu; Ruikang Wang; Zhenhe Ma
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Paper Abstract

Unilateral carotid artery ligation which could induce adaptive improvement is a classic model that has been widely used to study pathology of ischemic disease. In those studies, blood flow is an important parameter to characterize the ischemia. Optical coherence tomography (OCT) is a powerful imaging modality which can provide depth resolved images in biological tissue with high spatial and temporal resolution. SPF rats was anesthetized with isoflurane and divided into two groups. In first group, bilateral carotid artery was surgically exposed, and then left carotid artery was ligated. Blood flow changes of the contralateral carotid artery was monitored using high speed spectral domain optical coherence tomography, including the absolute flow velocity and the flow volume. In the other group, skull window was opened at the ipsilateral cerebral cortex of ligation and blood supply of small artery was measured before and after the ligation. The measured results demonstrate the blood supply compensation process after unilateral carotid artery ligation. With the superiority of high resolution, OCT is an effective technology in monitoring results of carotid artery after ligation.

Paper Details

Date Published: 17 March 2016
PDF: 6 pages
Proc. SPIE 9707, Dynamics and Fluctuations in Biomedical Photonics XIII, 97070D (17 March 2016); doi: 10.1117/12.2212278
Show Author Affiliations
Yushu Ma, Northeastern Univ. (China)
Chengbo Liang, Shenzhen Entry-Exit Inspection and Quarantine Bureau (China)
Yanyan Suo, Shenzhen Entry-Exit Inspection and Quarantine Bureau (China)
Yuqian Zhao, Northeastern Univ. (China)
Yi Wang, Northeastern Univ. (China)
Tao Xu, Academy of Metrology and Quality Inspection of Shenzhen (China)
Ruikang Wang, Univ. of Washington (United States)
Zhenhe Ma, Northeastern Univ. (China)


Published in SPIE Proceedings Vol. 9707:
Dynamics and Fluctuations in Biomedical Photonics XIII
Valery V. Tuchin; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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