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Proceedings Paper

Two-photon photodynamic properties of TBO-AuNR-in-shell nanoparticles (Conference Presentation)
Author(s): Cheng-Han Wu; Chen-Sheng Yeh; Fong-Yu Cheng; Zen-Uong Tsai; Tzu-Ming Liu

Paper Abstract

Photodynamic therapy (PDT) is a light-activated chemotherapeutic treatment that utilizes singlet oxygen and reactive oxygen species induced oxidative reactions to react with surrounding biological substrates, which either kills or irreversibly damages malignant cells. We used multiphoton nonlinear optical microscopy to observe the photo-dynamic effects of TBO-AuNR-in-shell NPs. Excited by femtosecond Cr:forsterite laser operating at 1230nm, singlet oxygen were generated through a plasmon-enhanced two-photon nonlinear optical process. For cells took up NPs, this photodynamic effect can kill the cell. From nonlinear optical microscopy images, we found they shrunk after 3 minutes of illumination.

Paper Details

Date Published: 26 April 2016
PDF: 1 pages
Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 96940S (26 April 2016); doi: 10.1117/12.2212229
Show Author Affiliations
Cheng-Han Wu, Institute of Biomedical Engineering, National Taiwan Univ. (Taiwan)
Chen-Sheng Yeh, National Cheng Kung Univ. (Taiwan)
Fong-Yu Cheng, National Cheng Kung Univ. (Taiwan)
Zen-Uong Tsai, National Taiwan Univ. (Taiwan)
Tzu-Ming Liu, National Taiwan Univ. (Taiwan)


Published in SPIE Proceedings Vol. 9694:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV
David H. Kessel; Tayyaba Hasan, Editor(s)

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