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Proceedings Paper

High-speed intravascular photoacoustic imaging of lipid-laden plaque at 1.7 micron (Conference Presentation)
Author(s): Jie Hui; Qianhuan Yu; Teng Ma; Pu Wang; Yingchun Cao; Rebecca Bruning; Yueqiao Qu; Zhongping Chen; Qifa Zhou; Michael Sturek; Weibiao Chen; Ji-Xin Cheng
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Paper Abstract

Lipid deposition inside the arterial wall is a hallmark of plaque vulnerability. Overtone absorption-based intravascular photoacoustic (IVPA) catheter is a promising technology for quantifying the amount of lipid and its spatial distribution inside the arterial wall. Thus far, the clinical translation of IVPA technology is limited by its slow imaging speed due to lack of a high-power and high-repetition-rate laser source for lipid-specific excitation at 1.7 μm. Here, we demonstrate a potassium titanyl phosphate-based optical parametric oscillator (OPO) with output pulse energy up to 2 mJ at a wavelength of 1724 nm and with a repetition rate of 500 Hz. This OPO enabled IVPA imaging at 1 frame per sec, which is about 50-fold faster than previously reported IVPA systems. The IVPA imaging system was characterized by a pencil lead and a lipid-mimicking phantom for its imaging resolution, sensitivity, and specificity, respectively. Its performance was further validated by ex vivo study of an atherosclerotic human femoral artery and comparison to gold standard histology.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 970804 (27 April 2016); doi: 10.1117/12.2212200
Show Author Affiliations
Jie Hui, Purdue Univ. (United States)
Qianhuan Yu, Shanghai Institute of Optics and Fine Mechanics (China)
Teng Ma, The Univ. of Southern California (United States)
Pu Wang, Purdue Univ. (United States)
Yingchun Cao, Purdue Univ. (United States)
Rebecca Bruning, Indiana Univ. (United States)
Yueqiao Qu, Univ. of California, Irvine (United States)
Zhongping Chen, Univ. of California, Irvine (United States)
Qifa Zhou, The Univ. of Southern California (United States)
Michael Sturek, Indiana Univ.-Purdue Univ. Indianapolis (United States)
Weibiao Chen, Shanghai Institute of Optics and Fine Mechanics (China)
Ji-Xin Cheng, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 9708:
Photons Plus Ultrasound: Imaging and Sensing 2016
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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