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Proceedings Paper

Endoscope-based beveled and volume fiber-optic Raman probes for in vivo diagnosis of gastric dysplasia: a comparative study
Author(s): Jianfeng Wang; Kan Lin; Wei Zheng; Khek Yu Ho; Ming Teh; Khay Guan Yeoh; Zhiwei Huang
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Paper Abstract

Raman spectroscopy is a unique optical vibrational spectroscopic technique which is capable of probing biochemical and biomolecular structures and conformations associated with disease transformation. Raman probe is a key component to facilitate the in vivo tissue diagnosis by using Raman spectroscopy. The diagnostic performance of the two different endoscope-based fiber-optic Raman probe designs (i.e., beveled and volume Raman probes) were evaluated for real-time, in vivo diagnosis of gastric dysplasia at endoscopy. The beveled Raman probe provides approximately 2-fold improvements in tissue Raman to autofluorescence intensity ratios as compared to the use of volume Raman probe. The diagnostic accuracy of gastric dysplasia using beveled Raman probe is 93.0% (sensitivity of 92.5%; specificity of 93.1%), which is superior to the diagnostic performance (accuracy of 88.4%; sensitivity of 85.8%; specificity of 88.6%) using the volume Raman probe. Biomolecular modeling is finally employed to extract the different Raman active components interrogated by the two types of endoscope-based Raman probes.

Paper Details

Date Published: 7 March 2016
PDF: 6 pages
Proc. SPIE 9704, Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry, 97040D (7 March 2016); doi: 10.1117/12.2212067
Show Author Affiliations
Jianfeng Wang, National Univ. of Singapore (Singapore)
Kan Lin, National Univ. of Singapore (Singapore)
Wei Zheng, National Univ. of Singapore (Singapore)
Khek Yu Ho, National Univ. of Singapore (Singapore)
National Univ. Hospital (Singapore)
Ming Teh, National Univ. of Singapore (Singapore)
National Univ. Hospital (Singapore)
Khay Guan Yeoh, National Univ. of Singapore (Singapore)
National Univ. Hospital (Singapore)
Zhiwei Huang, National Univ. of Singapore (Singapore)


Published in SPIE Proceedings Vol. 9704:
Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry
Anita Mahadevan-Jansen; Wolfgang Petrich, Editor(s)

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