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Proceedings Paper

A wearable conformal bandage for non-invasive two-dimensional imaging of skin oxygenation (Conference Presentation)
Author(s): Zongxi Li; Emmanuel Roussakis; Emily Keeley; Gabriela Apiou-Sbirlea; Reginald Birngruber; Christene Huang; Conor L. Evans
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Paper Abstract

The complex surface topology and soft mechanics of the skin poses a considerable challenge to the development of wearable, conformal sensors. As a results, current clinical assessments of healing-related skin parameters often rely on bulky and expensive optical systems that are difficult to deploy at the point of care. Here, using a rapid-drying, liquid bandage containing oxygen-sensing molecules, we created a wearable sensor bandage that conforms the surface geometry of skin and wounds, and provides two-dimensional maps of cutaneous oxygenation in a non-disruptive fashion. Custom oxygen sensing phosphors have been developed in house that are at least five times brighter than the commercial sensing molecules, enabling the visualization of oxygen concentration using a simple color camera or even by eye under ambient lighting conditions. The oxygen-sensing bandage has been applied to monitor tissue ischemia, graft integration, as well as the progression of burn in animal models. Recent studies have demonstrated its ability to track and quantify skin inflammation induced by complete Freund’s adjuvant in an in vivo porcine model.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 97150R (27 April 2016); doi: 10.1117/12.2211887
Show Author Affiliations
Zongxi Li, Massachusetts General Hospital (United States)
Emmanuel Roussakis, Massachusetts General Hospital (United States)
Emily Keeley, Massachusetts Institute of Technology (United States)
Gabriela Apiou-Sbirlea, Massachusetts General Hospital (United States)
Reginald Birngruber, Univ. zu Lübeck (Germany)
Christene Huang, Massachusetts General Hospital (United States)
Conor L. Evans, Massachusetts General Hospital (United States)

Published in SPIE Proceedings Vol. 9715:
Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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