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Proceedings Paper

Towards the mid-infrared optical biopsy
Author(s): Angela B. Seddon; Trevor M. Benson; Slawomir Sujecki; Nabil Abdel-Moneim; Zhuoqi Tang; David Furniss; Lukasz Sojka; Nick Stone; Nallala Jayakrupakar; Gavin Rhys Lloyd; Ian Lindsay; Jon Ward; Mark Farries; Peter M. Moselund; Bruce Napier; Samir Lamrini; Uffe Møller; Irnis Kubat; Christian R. Petersen; Ole Bang
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Paper Abstract

We are establishing a new paradigm in mid-infrared molecular sensing, mapping and imaging to open up the midinfrared spectral region for in vivo (i.e. in person) medical diagnostics and surgery. Thus, we are working towards the mid-infrared optical biopsy (‘opsy’ look at, bio the biology) in situ in the body for real-time diagnosis. This new paradigm will be enabled through focused development of devices and systems which are robust, functionally designed, safe, compact and cost effective and are based on active and passive mid-infrared optical fibers. In particular, this will enable early diagnosis of external cancers, mid-infrared detection of cancer-margins during external surgery for precise removal of diseased tissue, in one go during the surgery, and mid-infrared endoscopy for early diagnosis of internal cancers and their precision removal. The mid-infrared spectral region has previously lacked portable, bright sources. We set a record in demonstrating extreme broad-band supercontinuum generated light 1.4 to 13.3 microns in a specially engineered, high numerical aperture mid-infrared optical fiber. The active mid-infrared fiber broadband supercontinuum for the first time offers the possibility of a bright mid-infrared wideband source in a portable package as a first step for medical fiber-based systems operating in the mid-infrared. Moreover, mid-infrared molecular mapping and imaging is potentially a disruptive technology to give improved monitoring of the environment, energy efficiency, security, agriculture and in manufacturing and chemical processing. This work is in part supported by the European Commission: Framework Seven (FP7) Large-Scale Integrated Project MINERVA: MId-to-NEaR- infrared spectroscopy for improVed medical diAgnostics (317803; www.minerva-project.eu).

Paper Details

Date Published: 7 March 2016
PDF: 7 pages
Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 970302 (7 March 2016); doi: 10.1117/12.2211584
Show Author Affiliations
Angela B. Seddon, The Univ. of Nottingham (United Kingdom)
Trevor M. Benson, The Univ. of Nottingham (United Kingdom)
Slawomir Sujecki, The Univ. of Nottingham (United Kingdom)
Nabil Abdel-Moneim, The Univ. of Nottingham (United Kingdom)
Zhuoqi Tang, The Univ. of Nottingham (United Kingdom)
David Furniss, The Univ. of Nottingham (United Kingdom)
Lukasz Sojka, The Univ. of Nottingham (United Kingdom)
Nick Stone, Univ. of Exeter (United Kingdom)
Nallala Jayakrupakar, Univ. of Exeter (United Kingdom)
Gavin Rhys Lloyd, Gloucestershire Royal Hospital (United Kingdom)
Ian Lindsay, Gooch Housego Ltd. (United Kingdom)
Jon Ward, Gooch Housego Ltd. (United Kingdom)
Mark Farries, Gooch Housego Ltd. (United Kingdom)
Peter M. Moselund, NKT Photonics A/S (Denmark)
Bruce Napier, Vivid Components Ltd. (Germany)
Samir Lamrini, LISA Laser Products (Germany)
Uffe Møller, DTU Fotonik (Denmark)
Irnis Kubat, DTU Fotonik (Denmark)
Christian R. Petersen, DTU Fotonik (Denmark)
Ole Bang, DTU Fotonik (Denmark)


Published in SPIE Proceedings Vol. 9703:
Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos, Editor(s)

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