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Proceedings Paper

Changes in neurocranium thickness in early childhood
Author(s): Niharika Gajawelli; Sean Deoni; Jie Shi; Liang Xu; Holly Dirks; Douglas Dean; Jonathan O'Muircheartaigh; Siddhant Sawardekar; Andrea Ezis; Marvin D. Nelson; Yalin Wang; Natasha Lepore
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Paper Abstract

Several developmental disorders involve shape abnormalities of the neurocranium, the most common one being craniosynostosis, that affects about 1 in 2000 infants. A key step in determining how these disorders affect neurodevelopment is to establish how the brain and neurocranium co-evolve in the normally developing child. However, due to the scarcity of normally developing infant and pediatric imaging data, there have been a lack of imaging studies pertaining to normal neurocranial development. Here, taking advantage of a large data bank of high quality brain MRI from healthy children ages 0-4 years old, and of a novel conformal geometry-based analysis pipeline, we have been determining a set of statistical atlases of the neurocranium, divided into age groups. In this first part of the study, we focus more specifically on a comparison of 1 and 2 year old infants. Characterizing neurocranium shape changes will enable us to understand how the cranial bones develop in relation to brain development. This in turn will allow a better determination of the effects of neurocranial disorders, which will help inform treatment strategies.

Paper Details

Date Published: 22 December 2015
PDF: 6 pages
Proc. SPIE 9681, 11th International Symposium on Medical Information Processing and Analysis, 96810I (22 December 2015); doi: 10.1117/12.2211502
Show Author Affiliations
Niharika Gajawelli, Children's Hospital Los Angeles (United States)
Univ. of Southern California (United States)
Sean Deoni, Children's Hospital Colorado (United States)
Brown Univ. (United States)
Jie Shi, Arizona State Univ. (United States)
Liang Xu, Arizona State Univ. (United States)
Holly Dirks, Brown Univ. (United States)
Douglas Dean, Brown Univ. (United States)
Jonathan O'Muircheartaigh, Brown Univ. (United States)
Siddhant Sawardekar, Children's Hospital Los Angeles (United States)
Andrea Ezis, Children's Hospital Los Angeles (United States)
Marvin D. Nelson, Univ. of Southern California (United States)
Children's Hospital Los Angeles (United States)
Yalin Wang, Arizona State Univ. (United States)
Natasha Lepore, Children's Hospital Los Angeles (United States)
Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 9681:
11th International Symposium on Medical Information Processing and Analysis
Eduardo Romero; Natasha Lepore; Juan D. García-Arteaga; Jorge Brieva, Editor(s)

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