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Proceedings Paper

Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease
Author(s): Rinat Ankri; Dorit Leshem-Lev; Eli I. Lev; Menachem Motiei; Edith Hochhauser; Dror Fixler
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Paper Abstract

In our study we aim to develop a new, simple and non-invasive method to detect and to treat atherosclerosis. We use gold nanoparticles (GNPs) combined with the diffusion reflection (DR) method to demonstrate the detection of vulnerable atherosclerotic plaques. Our method is based on the fact that macrophages are a major component in the vulnerable plaque and are able to uptake metal nanoparticles that can be discovered by the DR system. Moreover, it is well known that high density lipoprotein (HDL) reduces ASVD by inhibiting pro-inflammatory factors, enabling the specific treatment of atherosclerosis.

Paper Details

Date Published: 22 April 2016
PDF: 10 pages
Proc. SPIE 9721, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII, 97210F (22 April 2016); doi: 10.1117/12.2211401
Show Author Affiliations
Rinat Ankri, Bar-Ilan Univ. (Israel)
Dorit Leshem-Lev, Rabin Medical Ctr. (Israel)
Eli I. Lev, Rabin Medical Ctr. (Israel)
Menachem Motiei, Bar-Ilan Univ. (Israel)
Edith Hochhauser, Rabin Medical Ctr. (Israel)
Dror Fixler, Bar-Ilan Univ. (Israel)

Published in SPIE Proceedings Vol. 9721:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII
Alexander N. Cartwright; Dan V. Nicolau; Dror Fixler, Editor(s)

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