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Proceedings Paper

Morphologic 3D scanning of fallopian tubes to assist ovarian cancer diagnosis
Author(s): Wendy-Julie Madore; Etienne De Montigny; Andréanne Deschênes; Fouzi Benboujja; Mikael Leduc; Anne-Marie Mes-Masson; Diane M. Provencher; Kurosh Rahimi; Caroline Boudoux; Nicolas Godbout
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Paper Abstract

Pathological evaluation of the fallopian tubes is an important diagnostic result but tumors can be missed using routine approaches. As the majority of high-grade serous ovarian cancers are now believed to originate in the fallopian tubes, pathological examination should include in a thorough examination of the excised ovaries and fallopian tubes. We present an dedicated imaging system for diagnostic exploration of human fallopian tubes. This system is based on optical coherence tomography (OCT), a laser imaging modality giving access to sub- epithelial tissue architecture. This system produces cross-sectional images up to 3 mm in depth, with a lateral resolution of ≈15μm and an axial resolution of ≈12μm. An endoscopic single fiber probe was developed to fit in a human fallopian tube. This 1.2 mm probe produces 3D volume data of the entire inner tube within a few minutes. To demonstrate the clinical potential of OCT for lesion identification, we studied 5 different ovarian lesions and healthy fallopian tubes. We imaged 52 paraffin-embedded human surgical specimens with a benchtop system and compared these images with histology slides. We also imaged and compared healthy oviducts from 3 animal models to find one resembling the human anatomy and to develop a functional ex vivo imaging procedure with the endoscopic probe. We also present an update on an ongoing clinical pilot study on women undergoing prophylactic or diagnostic surgery in which we image ex vivo fallopian tubes with the endoscopic probe.

Paper Details

Date Published: 29 February 2016
PDF: 9 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96894D (29 February 2016); doi: 10.1117/12.2211204
Show Author Affiliations
Wendy-Julie Madore, Ecole Polytechnique de Montréal (Canada)
Ctr. Hospitalier Univ. de Montréal (Canada)
Institut du Cancer de Montréal (Canada)
Etienne De Montigny, Ecole Polytechnique de Montréal (Canada)
Ctr. Hospitalier Univ. de Montréal (Canada)
Institut du Cancer de Montréal (Canada)
Andréanne Deschênes, Ecole Polytechnique de Montréal (Canada)
Fouzi Benboujja, Ecole Polytechnique de Montréal (Canada)
Mikael Leduc, Ecole Polytechnique de Montréal (Canada)
Anne-Marie Mes-Masson, Ctr. Hospitalier Univ. de Montréal (Canada)
Institut du Cancer de Montréal (Canada)
Diane M. Provencher, Ctr. Hospitalier Univ. de Montréal (Canada)
Institut du Cancer de Montréal (Canada)
Kurosh Rahimi, Ctr. Hospitalier Univ. de Montréal (Canada)
Institut du Cancer de Montréal (Canada)
Caroline Boudoux, Ecole Polytechnique de Montréal (Canada)
Nicolas Godbout, Ecole Polytechnique de Montréal (Canada)


Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney; Melissa C. Skala; Bernard Choi; Andreas Mandelis; Brian J. F. Wong; Justus F. Ilgner; Nikiforos Kollias; Paul J. Campagnola; Kenton W. Gregory; Laura Marcu; Haishan Zeng, Editor(s)

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