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Proceedings Paper

Noninvasive skin cancer diagnosis using multimodal optical spectroscopy
Author(s): Austin J. Moy; Xu Feng; Mia K. Markey; Jason S. Reichenberg; James W. Tunnell
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Paper Abstract

Skin cancer is the most common form of cancer in the United States and is a recognized public health issue. Diagnosis of skin cancer involves biopsy of the suspicious lesion followed by histopathology. Biopsies, which involve excision of the lesion, are invasive, at times unnecessary, and are costly procedures (~$2.8B/year in the US). An unmet critical need exists to develop a non-invasive and inexpensive screening method that can eliminate the need for unnecessary biopsies. To address this need, our group has reported on the continued development of a multimodal spectroscopy (MMS) system towards the goal of a spectral biopsy of skin. Our approach combines Raman spectroscopy, fluorescence spectroscopy, and diffuse reflectance spectroscopy to collect comprehensive optical property information from suspicious skin lesions. We describe our present efforts to develop an updated MMS system composed of OEM components that will be smaller, less expensive, and more clinic-friendly than the previous system. Key system design choices include the selection of miniature spectrometers, a fiber-coupled broadband light source, a fiber coupled diode laser, and a revised optical probe. Selection of these components results in a ~50% reduction in system footprint, resulting in a more clinic-friendly system. We also present preliminary characterization data from the updated MMS system, showing similar performance with our revised optical probe design. Finally, we present in vivo skin measurements taken with the updated MMS system. Future work includes the initiation of a clinical study (n = 250) of the MMS system to characterize its performance in identifying skin cancers.

Paper Details

Date Published: 29 February 2016
PDF: 6 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 968905 (29 February 2016); doi: 10.1117/12.2211172
Show Author Affiliations
Austin J. Moy, The Univ. of Texas at Austin (United States)
Xu Feng, The Univ. of Texas at Austin (United States)
Mia K. Markey, The Univ. of Texas at Austin (United States)
The Univ. of Texas MD Anderson Cancer Ctr. (United States)
Jason S. Reichenberg, The Univ. of Texas at Austin (United States)
James W. Tunnell, The Univ. of Texas at Austin (United States)

Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney; Kenton W. Gregory; Laura Marcu; Melissa C. Skala; Paul J. Campagnola; Bernard Choi; Nikiforos Kollias; Haishan Zeng; Andreas Mandelis; Brian J. F. Wong; Justus F. Ilgner, Editor(s)

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