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Proceedings Paper

Signal and response properties indicate an optoacoustic effect underlying the intra-cochlear laser-optical stimulation
Author(s): Nicole Kallweit; Peter Baumhoff; Alexander Krueger; Nadine Tinne; Alexander Heisterkamp; Andrej Kral; Hannes Maier; Tammo Ripken
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Paper Abstract

Optical cochlea stimulation is under investigation as a potential alternative to conventional electric cochlea implants in treatment of sensorineural hearing loss. If direct optical stimulation of spiral ganglion neurons (SGNs) would be feasible, a smaller stimulation volume and, therefore, an improved frequency resolution could be achieved. However, it is unclear whether the mechanism of optical stimulation is based on direct neuronal stimulation or on optoacoustics. Animal studies on hearing vs. deafened guinea pigs already identified the optoacoustic effect as potential mechanism for intra-cochlear optical stimulation. In order to characterize the optoacoustic stimulus more thoroughly the acoustic signal along the beam path of a pulsed laser in water was quantified and compared to the neuronal response properties of hearing guinea pigs stimulated with the same laser parameters. Two pulsed laser systems were used for analyzing the influence of variable pulse duration, pulse energy, pulse peak power and absorption coefficient. Preliminary results of the experiments in water and in vivo suggesta similar dependency of response signals on the applied laser parameters: Both datasets show an onset and offset signal at the beginning and the end of the laser pulse. Further, the resulting signal amplitude depends on the pulse peak power as well as the temporal development of the applied laser pulse. The data indicates the maximum of the first derivative of power as the decisive factor. In conclusion our findings strengthen the hypothesis of optoacoustics as the underlying mechanism for optical stimulation of the cochlea.

Paper Details

Date Published: 1 March 2016
PDF: 6 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96892G (1 March 2016); doi: 10.1117/12.2210926
Show Author Affiliations
Nicole Kallweit, Laser Zentrum Hannover e.V. (Germany)
Cluster of Excellence "Hearing4all" (Germany)
Peter Baumhoff, Hannover Medical School (Germany)
Alexander Krueger, Laser Zentrum Hannover e.V. (Germany)
Cluster of Excellence "Hearing4all" (Germany)
Nadine Tinne, Laser Zentrum Hannover e.V. (Germany)
Alexander Heisterkamp, Laser Zentrum Hannover e.V. (Germany)
Leibniz Univ. Hannover (Germany)
Cluster of Excellence "Hearing4all" (Germany)
Andrej Kral, Hannover Medical School (Germany)
Cluster of Excellence "Hearing4all" (Germany)
Hannes Maier, Hannover Medical School (Germany)
Cluster of Excellence "Hearing4all" (Germany)
Tammo Ripken, Laser Zentrum Hannover e.V. (Germany)
Cluster of Excellence "Hearing4all" (Germany)

Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney M.D.; Melissa C. Skala; Bernard Choi; Andreas Mandelis; Brian J. F. Wong M.D.; Justus F. Ilgner M.D.; Nikiforos Kollias; Paul J. Campagnola; Kenton W. Gregory M.D.; Laura Marcu; Haishan Zeng, Editor(s)

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