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Proceedings Paper

Sensitivity of quantitative photoacoustic tomography inversion schemes to experimental uncertainty
Author(s): Martina Fonseca; Teedah Saratoon; Bajram Zeqiri; Paul Beard; Ben Cox
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Paper Abstract

The ability to accurately quantify chromophore concentration from photoacoustic images would have a major impact on pre-clinical and clinical imaging. Recent years have seen significant advances in the theoretical understanding of quantitative photoacoustic imaging and in the development of model-based inversion strategies that overcome issues such as non-uniqueness and non-linearity. Nevertheless, their full in vivo implementation has not successfully been achieved, partially because experimental uncertainties complicate the transition. In this study, a sensitivity analysis is performed to assess the impact on accuracy of having uncertainty in critical experimental parameters such as scattering, beam diameter, beam position and calibration factor. This study was performed using two virtual phantoms, at one illumination and four optical wavelengths. The model-based inversion was applied in 3 variants - one just inverting for chromophores and two others further inverting for either a scaling factor or the scatterer concentration. The performance of these model-based inversions is also compared to linear unmixing strategies - with and without fluence correction. The results show that experimental uncertainties in a priori fixed parameters - especially calibration factor and scatterer concentration - significantly affect accuracy of model-based inversions and therefore measures to ameliorate this uncertainty should be considered. Including a scaling parameter in the inversion appears to improve quantification estimates. Furthermore, even with realistic levels of experimental uncertainty in model-based input parameters, they outperform linear unmixing approaches. If parameter uncertainty is large and has significant impact on accuracy, the parameter can be included as an unknown in model-based schemes.

Paper Details

Date Published: 18 March 2016
PDF: 14 pages
Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97084X (18 March 2016); doi: 10.1117/12.2210916
Show Author Affiliations
Martina Fonseca, Univ. College London (United Kingdom)
Teedah Saratoon, Univ. College London (United Kingdom)
Bajram Zeqiri, National Physical Lab. (United Kingdom)
Paul Beard, Univ. College London (United Kingdom)
Ben Cox, Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 9708:
Photons Plus Ultrasound: Imaging and Sensing 2016
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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