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Proceedings Paper

Feasibility of OCT to detect radiation-induced esophageal damage in small animal models (Conference Presentation)
Author(s): Pouya Jelvehgaran; Tanja Alderliesten; Javier Salguero; Gerben Borst; Ji-Ying Song; Ton G. van Leeuwen; Johannes F. de Boer; Daniel M. de Bruin; Marcel B. van Herk
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Paper Abstract

Lung cancer survival is poor and radiotherapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to reduced food intake or even fistula formation. Only few direct techniques exist to measure radiation-induced esophageal damage, for which knowledge is needed to improve the balance between risk of tumor recurrence and complications. Optical coherence tomography (OCT) is a minimally-invasive imaging technique that obtains cross-sectional, high-resolution (1-10µm) images and is capable of scanning the esophageal wall up to 2-3mm depth. In this study we investigated the feasibility of OCT to detect esophageal radiation damage in mice. In total 30 mice were included in 4 study groups (1 main and 3 control groups). Mice underwent cone-beam CT imaging for initial setup assessment and dose planning followed by single-fraction dose delivery of 4, 10, 16, and 20Gy on 5mm spots, spaced 10mm apart. Mice were repeatedly imaged using OCT: pre-irradiation and up to 3 months post-irradiation. The control groups received either OCT only, irradiation only, or were sham-operated. We used histopathology as gold standard for radiation-induced damage diagnosis. The study showed edema in both the main and OCT-only groups. Furthermore, radiation-induced damage was primarily found in the highest dose region (distal esophagus). Based on the histopathology reports we were able to identify the radiation-induced damage in the OCT images as a change in tissue scattering related to the type of induced damage. This finding indicates the feasibility and thereby the potentially promising role of OCT in radiation-induced esophageal damage assessment.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III, 96910S (27 April 2016); doi: 10.1117/12.2210829
Show Author Affiliations
Pouya Jelvehgaran, Academisch Medisch Centrum (Netherlands)
Institute for Laser Life and Biophotonics (Netherlands)
Tanja Alderliesten, Academisch Medisch Centrum (Netherlands)
Javier Salguero, The Netherlands Cancer Institute (Netherlands)
Gerben Borst, The Netherlands Cancer Institute (Netherlands)
Ji-Ying Song, The Netherlands Cancer Institute (Netherlands)
Ton G. van Leeuwen, Academisch Medisch Centrum (Netherlands)
Johannes F. de Boer, Vrije Univ. Amsterdam (Netherlands)
Institute for Lasers, Life and Biophotonics Amsterdam (Netherlands)
Daniel M. de Bruin, Academisch Medisch Centrum (Netherlands)
Marcel B. van Herk, The Univ. of Manchester (United Kingdom)
Academisch Medisch Centrum (Netherlands)

Published in SPIE Proceedings Vol. 9691:
Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III
Melissa J. Suter; Guillermo J. Tearney; Thomas D. Wang; Stephen Lam; Matthew Brenner, Editor(s)

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