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Proceedings Paper

Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography
Author(s): Ekaterina V. Gubarkova; Varvara V. Dudenkova; Felix I. Feldchtein; Lidia B. Timofeeva; Elena B. Kiseleva; Sergei S. Kuznetsov; Alexander A. Moiseev; Gregory V. Gelikonov; Alex I. Vitkin; Natalia D. Gladkova
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Paper Abstract

We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers in the development of the atherosclerotic plaque (AP). The study shows potential of CP OCT for the assessment of collagen and elastin fibers condition in atherosclerotic arteries. Specifically, the additional information afforded by CP OCT, related to birefringence and cross-scattering properties of arterial tissues, may improve the robustness and accuracy of assessment about the microstructure and composition of the plaque for different stages of atherosclerosis.

Paper Details

Date Published: 29 February 2016
PDF: 7 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96893F (29 February 2016); doi: 10.1117/12.2210822
Show Author Affiliations
Ekaterina V. Gubarkova, Nizhny Novgorod State Medical Academy (Russian Federation)
Varvara V. Dudenkova, Nizhny Novgorod State Medical Academy (Russian Federation)
N.I. Lobachevsky State Univ. of Nizhni Novgorod (Russian Federation)
Felix I. Feldchtein, Nizhny Novgorod State Medical Academy (Russian Federation)
Lidia B. Timofeeva, Nizhny Novgorod State Medical Academy (Russian Federation)
Elena B. Kiseleva, Nizhny Novgorod State Medical Academy (Russian Federation)
Sergei S. Kuznetsov, Nizhny Novgorod State Medical Academy (Russian Federation)
Alexander A. Moiseev, Institute of Applied Physics (Russian Federation)
Gregory V. Gelikonov, Nizhny Novgorod State Medical Academy (Russian Federation)
Institute of Applied Physics (Russian Federation)
Alex I. Vitkin, Nizhny Novgorod State Medical Academy (Russian Federation)
Univ. of Toronto (Canada)
Ontario Cancer Institute (Canada)
Natalia D. Gladkova, Nizhny Novgorod State Medical Academy (Russian Federation)


Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney; Melissa C. Skala; Bernard Choi; Andreas Mandelis; Brian J. F. Wong; Justus F. Ilgner; Nikiforos Kollias; Paul J. Campagnola; Kenton W. Gregory; Laura Marcu; Haishan Zeng, Editor(s)

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