Share Email Print
cover

Proceedings Paper

Reliability analysis of instrument design of noninvasive bone marrow disease detector
Author(s): Yu Su; Ting Li; Yunlong Sun
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Bone marrow is an important hematopoietic organ, and bone marrow lesions (BMLs) may cause a variety of complications with high death rate and short survival time. Early detection and follow up care are particularly important. But the current diagnosis methods rely on bone marrow biopsy/puncture, with significant limitations such as invasion, complex operation, high risk, and discontinuous. It is highly in need of a non-invasive, safe, easily operated, and continuous monitoring technology. So we proposed to design a device aimed for detecting bone marrow lesions, which was based on near infrared spectrum technology. Then we fully tested its reliabilities, including the sensitivity, specificity, signal-to-noise ratio (SNR), stability, and etc. Here, we reported this sequence of reliability test experiments, the experimental results, and the following data analysis. This instrument was shown to be very sensitive, with distinguishable concentration less than 0.002 and with good linearity, stability and high SNR. Finally, these reliability-test data supported the promising clinical diagnosis and surgery guidance of our novel instrument in detection of BMLs.

Paper Details

Date Published: 29 February 2016
PDF: 8 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96894R (29 February 2016); doi: 10.1117/12.2210781
Show Author Affiliations
Yu Su, Univ. of Electronic Science and Technology of China (China)
Ting Li, Univ. of Electronic Science and Technology of China (China)
Yunlong Sun, Univ. of Electronic Science and Technology of China (China)


Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney; Melissa C. Skala; Bernard Choi; Andreas Mandelis; Brian J. F. Wong; Justus F. Ilgner; Nikiforos Kollias; Paul J. Campagnola; Kenton W. Gregory; Laura Marcu; Haishan Zeng, Editor(s)

© SPIE. Terms of Use
Back to Top