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Proceedings Paper

Study of erythrocyte membrane fluctuation using light scattering analysis
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Paper Abstract

It is commonly known that alteration of erythrocyte deformability lead to serious microcirculatory diseases such as retinopathy, nephropathy, etc. Various methods and technologies have been developed to diagnose such membrane properties of erythrocytes. In this study, we developed an innovative method to measure hemorheological characteristics of the erythrocyte membrane using a light scattering analysis with simplified optic setting and multi-cell analysis as well. Light scattering intensity through multiple erythrocytes and its power density spectrum were obtained. The results of light scattering analyses were compared in healthy control and artificially hardened sample which was treated with glutaraldehyde. These results were further compared with conventional assays to measure deformable property in hemorheology. We found that light scattering information would reflect the disturbance of membrane fluctuation in artificially damaged erythrocytes. Therefore, measuring fluctuation of erythrocyte membrane using light scattering signal could facilitate simple and precise diagnose of pathological state on erythrocyte as well as related complications.

Paper Details

Date Published: 9 March 2016
PDF: 4 pages
Proc. SPIE 9718, Quantitative Phase Imaging II, 971818 (9 March 2016); doi: 10.1117/12.2210777
Show Author Affiliations
Hoyoon Lee, Korea Univ. (Korea, Republic of)
Sangyun Lee, Korea Advanced Institute of Science and Technology (Korea, Republic of)
YongKeun Park, Korea Advanced Institute of Science and Technology (Korea, Republic of)
Sehyun Shin, Korea Univ. (Korea, Republic of)

Published in SPIE Proceedings Vol. 9718:
Quantitative Phase Imaging II
Gabriel Popescu; YongKeun Park, Editor(s)

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