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Proceedings Paper

In vivo imaging of pulmonary nodule and vasculature using endoscopic co-registered optical coherence tomography and autofluorescence imaging (Conference Presentation)
Author(s): Hamid Pahlevaninezhad; Anthony Lee; Geoffrey Hohert; Carely Schwartz; Tawimas Shaipanich; Alexander J. Ritchie; Wei Zhang; Calum E. MacAulay; Stephen Lam; Pierre M. Lane
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Paper Abstract

Peripheral lung nodules found by CT-scans are difficult to localize and biopsy bronchoscopically particularly for those ≤ 2 cm in diameter. In this work, we present the results of endoscopic co-registered optical coherence tomography and autofluorescence imaging (OCT-AFI) of normal and abnormal peripheral airways from 40 patients using 0.9 mm diameter fiber optic rotary pullback catheter. Optical coherence tomography (OCT) can visualize detailed airway morphology endoscopically in the lung periphery. Autofluorescence imaging (AFI) can visualize fluorescing tissue components such as collagen and elastin, enabling the detection of airway lesions with high sensitivity. Results indicate that AFI of abnormal airways is different from that of normal airways, suggesting that AFI can provide a sensitive visual presentation for rapidly identifying possible sites of pulmonary nodules. AFI can also rapidly visualize in vivo vascular networks using fast scanning parameters resulting in vascular-sensitive imaging with less breathing/cardiac motion artifacts compared to Doppler OCT imaging. It is known that tumor vasculature is structurally and functionally different from normal vessels. Thus, AFI can be potentially used for differentiating normal and abnormal lung vasculature for studying vascular remodeling.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III, 96910Y (27 April 2016); doi: 10.1117/12.2209686
Show Author Affiliations
Hamid Pahlevaninezhad, The BC Cancer Agency Research Ctr. (Canada)
Anthony Lee, The BC Cancer Agency Research Ctr. (Canada)
Geoffrey Hohert, The BC Cancer Agency Research Ctr. (Canada)
Carely Schwartz, The BC Cancer Agency Research Ctr. (Canada)
Tawimas Shaipanich, The BC Cancer Agency Research Ctr. (Canada)
Alexander J. Ritchie, The BC Cancer Agency Research Ctr. (Canada)
Wei Zhang, The BC Cancer Agency Research Ctr. (Canada)
Calum E. MacAulay, The BC Cancer Agency Research Ctr. (Canada)
Stephen Lam, The BC Cancer Agency Research Ctr. (Canada)
Pierre M. Lane, The BC Cancer Agency Research Ctr. (Canada)


Published in SPIE Proceedings Vol. 9691:
Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III
Melissa J. Suter; Stephen Lam; Matthew Brenner; Guillermo J. Tearney; Thomas D. Wang, Editor(s)

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