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Proceedings Paper

Morphological characterization of keratoconus-affected human corneas by SHG imaging and correlation analysis
Author(s): R. Mercatelli; F. Ratto; F. Tatini; F. Rossi; L. Menabuoni; R. Nicoletti; R. Pini; Frederick Pavone; R. Cicchi
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Paper Abstract

Keratoconus is an ophthalmic disease in which the cornea acquires an abnormal conical shape that prevents the correct focusing on the retina, causing visual impairment. The late diagnosis of keratoconus is among the principal causes of corneal transplantation surgery. In this study, we characterize the morphology of keratoconic corneas by means of the correlation of SHG images, finding that keratoconus can be diagnosed by analyzing the inclination of lamellae below Bowman’s membrane. In addition, imaging performed with both sagittal and “en face” geometry demonstrated that this morphological features can be highlighted both ex vivo and in vivo.

Paper Details

Date Published: 4 March 2016
PDF: 6 pages
Proc. SPIE 9693, Ophthalmic Technologies XXVI, 96930Y (4 March 2016); doi: 10.1117/12.2209618
Show Author Affiliations
R. Mercatelli, National Institute of Optics, National Research Council (Italy)
F. Ratto, Istituto di Fisica Applicata "Nello Carrara" (Italy)
F. Tatini, Istituto di Fisica Applicata "Nello Carrara" (Italy)
F. Rossi, Istituto di Fisica Applicata "Nello Carrara" (Italy)
L. Menabuoni, Public Hospital of Prato (Italy)
R. Nicoletti, Costruzione Strumenti Oftalmici srl (Italy)
R. Pini, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Frederick Pavone, European Lab. for Non-linear Spectroscopy, Univ. of Florence (Italy)
R. Cicchi, National Institute of Optics, National Research Council (Italy)

Published in SPIE Proceedings Vol. 9693:
Ophthalmic Technologies XXVI
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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