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Proceedings Paper

Identification of GI cancers utilising rapid mid-infrared spectral imaging
Author(s): Jayakrupakar Nallala; Gavin R. Lloyd; Catherine Kendall; Hugh Barr; Neil Shepherd; Nick Stone
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Paper Abstract

Pathologists find it notoriously difficult to provide both inter- and intra-observer agreement on a diagnosis of early gastrointestinal cancers. Vibrational spectroscopic approaches have shown their value in providing molecular compositional data from tissue samples and therefore enabling the identification of disease specific changes, when combined with multivariate techniques. Mid-infrared microscopic imaging is undergoing rapid developments in sources, detectors and spectrometers. Here we explore the use of high magnification FTIR for GI cancers and consider how the MINERVA (MId- to NEaR infrared spectroscopy for improVed medical diAgnostics) project, which is developing discrete frequency IR imaging tools will enable histopathologists to obtain rapid molecular images form unstained tissue sections.

Paper Details

Date Published: 7 March 2016
PDF: 7 pages
Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 970303 (7 March 2016); doi: 10.1117/12.2209363
Show Author Affiliations
Jayakrupakar Nallala, Univ. of Exeter (United Kingdom)
Gavin R. Lloyd, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Catherine Kendall, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Hugh Barr, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Neil Shepherd, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Nick Stone, Univ. of Exeter (United Kingdom)
Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)


Published in SPIE Proceedings Vol. 9703:
Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos, Editor(s)

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