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Proceedings Paper

Characterization of homogeneous tissue phantoms for performance tests in diffuse optics
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Paper Abstract

Solid homogeneous turbid phantoms can be employed to mimic the attenuation and angular distribution of light emerging from tissue, e.g., to assess the responsivity of the detection system of diffuse optics instrumentation and to support standardized performance tests of functional near-infrared spectroscopy devices. We present three methods to quantify the wavelength-dependent diffuse transmittance, relying on (1) measurement of radiance exiting the phantom by a detector far from the exit aperture, (2) simple recording of radiance by a power meter close to the exit aperture and correction for the finite distance between phantom surface and detector, (3) determination of the reduced scattering and absorption coefficients by time-resolved diffuse transmittance measurements and forward calculation of the time-integrated diffuse transmittance based on the diffusion model. The implications of the different approximations related to these approaches are discussed. The various methods were applied to characterize solid slab phantoms, and the results were compared. Specifically, for an epoxy-resin based phantom having a thickness of 2 cm, a reduced scattering coefficient of about 0.5/mm and an absorption coefficient of about 0.01/mm, the diffuse transmittance values obtained by the three different methods were found to agree within about 10%.

Paper Details

Date Published: 18 March 2016
PDF: 7 pages
Proc. SPIE 9700, Design and Quality for Biomedical Technologies IX, 970004 (18 March 2016); doi: 10.1117/12.2209038
Show Author Affiliations
Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)
Dieter Richard Taubert, Physikalisch-Technische Bundesanstalt (Germany)
Tsukasa Funane, Hitachi, Ltd. (Japan)
Masashi Kiguchi, Hitachi, Ltd. (Japan)
Hideo Eda, The Graduate School for the Creation of New Photonics Industries (Japan)
Antonio Pifferi, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie (Italy)
Rainer Macdonald, Physikalisch-Technische Bundesanstalt (Germany)

Published in SPIE Proceedings Vol. 9700:
Design and Quality for Biomedical Technologies IX
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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