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Proceedings Paper

SECM half-inch tethered endoscopic capsule (HITEC) for esophageal imaging (Conference Presentation)
Author(s): DongKyun Kang; Minkyu Kim; Robert W. Carruth; Weina Lu; Tao Wu; Sanaz Alali; Dukho Do; Amna R. Soomro; Catriona N. Grant; Aubrey R. Tiernan; Mireille Rosenberg; Norman S. Nishioka; Guillermo J. Tearney
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Paper Abstract

Spectrally encoded confocal microscopy (SECM) is a high-speed confocal endomicroscopy technology that can image extremely large regions of human tissue at cellular resolution within a short imaging time. Previously, we have developed a 7-mm-diameter SECM endoscopic capsule and successfully demonstrated imaging of human esophagus in vivo. Even though we were able to successfully capture images with the previous capsule, it suffered from two limitations: (1) the capsule had a small diameter, which provided a limited contact between SECM capsule and esophagus; and (2) speckle noise in SECM images made it challenging to appreciate cellular features. In this paper, we present a new SECM capsule, termed SECM half-inch tethered endoscopic capsule (HITEC), which addresses the two aforementioned technical challenges. With the SECM HITEC, a dual-clad fiber was used to reduce the speckle noise. Miniature GRIN optics was used to increase the NA of the fiber from 0.09 to 0.25, which made it possible to build a SECM capsule with large diameter (12.7 mm) while maintaining a short rigid length (22 mm). A water-immersion objective lens was custom designed and manufactured to provide high NA of 0.7. We have manufactured the SECM HITEC catheter and tested its optical and mechanical performance. Lateral and axial resolution was measured as 1.2 µm and 13 µm, respectively. We have imaged swine esophageal tissues ex vivo, and SECM images clearly visualized cell nuclei. Non-uniform rotational distortion (NURD) was small, less than 5%. Preliminary results suggest that SECM HITEC provides sufficient optical and mechanical performance for tissue imaging. In a future clinical study, we will test the feasibility of utilizing SECM HITEC for improved cellular imaging human of the human esophagus in vivo.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III, 96910M (27 April 2016); doi: 10.1117/12.2208942
Show Author Affiliations
DongKyun Kang, Massachusetts General Hospital (United States)
Minkyu Kim, Massachusetts General Hospital (United States)
Robert W. Carruth, Massachusetts General Hospital (United States)
Weina Lu, Massachusetts General Hospital (United States)
Tao Wu, Massachusetts General Hospital (United States)
Sanaz Alali, Massachusetts General Hospital (United States)
Dukho Do, Massachusetts General Hospital (United States)
Amna R. Soomro, Massachusetts General Hospital (United States)
Catriona N. Grant, Massachusetts General Hospital (United States)
Aubrey R. Tiernan, Massachusetts General Hospital (United States)
Mireille Rosenberg, Massachusetts General Hospital (United States)
Norman S. Nishioka, Massachusetts General Hospital (United States)
Guillermo J. Tearney, Massachusetts General Hospital (United States)

Published in SPIE Proceedings Vol. 9691:
Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III
Melissa J. Suter; Guillermo J. Tearney; Thomas D. Wang; Stephen Lam; Matthew Brenner, Editor(s)

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