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Proceedings Paper

Characterizing intestinal strictures with acoustic resolution photoacoustic microscopy
Author(s): Hao Lei; Guan Xu; Shengchun Liu; Laura A. Johnson; David S. Moons; Peter D. R. Higgins; Michael D. Rice; Jun Ni; Xueding Wang
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Paper Abstract

Crohn’s disease (CD) is an autoimmune disease, which may cause obstructing intestinal strictures due to inflammation, fibrosis (deposition of collagen), or a combination of both. Identifying the different stages of the disease progression is still challenging. In this work, we indicated the feasibility of non-invasively characterizing intestinal strictures using photoacoustic imaging (PAI), utilizing the uniquely optical absorption of hemoglobin and collagen. Surgically removed human intestinal stricture specimens were investigated with a prototype PAI system. 2D PA images with acoustic resolution at wavelength 532, 1210 and 1310 nm were formulated, and furthermore, the PA histochemical components images which show the microscopic distributions of histochemical components were solved. Imaging experiments on surgically removed human intestinal specimens has demonstrated the solved PA images were significantly different associated with the presence of fibrosis, which could be applied to characterize the intestinal strictures for given specimens.

Paper Details

Date Published: 15 March 2016
PDF: 6 pages
Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97080K (15 March 2016); doi: 10.1117/12.2208902
Show Author Affiliations
Hao Lei, Univ. of Michigan Medical School (United States)
Guan Xu, Univ. of Michigan (United States)
Shengchun Liu, Univ. of Michigan Medical School (United States)
Laura A. Johnson, Univ. of Michigan Medical School (United States)
David S. Moons, Univ. of Michigan Medical School (United States)
Peter D. R. Higgins, Univ. of Michigan Medical School (United States)
Michael D. Rice, Univ. of Michigan Medical School (United States)
Jun Ni, Univ. of Michigan Medical School (United States)
Xueding Wang, Univ. of Michigan (United States)
Univ. of Michigan Medical School (United States)


Published in SPIE Proceedings Vol. 9708:
Photons Plus Ultrasound: Imaging and Sensing 2016
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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