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Proceedings Paper

Combined label-free optical and optoacoustic imaging of model organisms at mesoscopy and microscopy resolutions
Author(s): Dominik Soliman; George J. Tserevelakis; Murad Omar; Vasilis Ntziachristos
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Paper Abstract

We present a multi-scale imaging system that integrates five optoacoustic and multi-photon modalities into the same device. The hybrid microscope offers a unique zoom-in ability by allowing for optoacoustic microscopy and mesoscopy scans of the sample within the same imaging framework. Furthermore, by combining several label-free modalities, we are able to visualize a broad range of anatomical features, taking advantage of their complementary contrast mechanisms. We characterize the spatial resolution and relative orientation of the different sub-modalities and demonstrate the system’s performance by the imaging of several model organisms ex vivo. The presented ability to dynamically vary scanning volume and resolution together with its multi-contrast and label-free imaging capabilities make the hybrid microscope a promising tool for comprehensive biological imaging.

Paper Details

Date Published: 15 March 2016
PDF: 7 pages
Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97083B (15 March 2016); doi: 10.1117/12.2208861
Show Author Affiliations
Dominik Soliman, Helmholtz Zentrum München (Germany)
Technische Univ. München (Germany)
George J. Tserevelakis, Foundation for Research and Technology (Greece)
Murad Omar, Helmholtz Zentrum München (Germany)
Technische Univ. München (Germany)
Vasilis Ntziachristos, Helmholtz Zentrum München (Germany)
Technische Univ. München (Germany)

Published in SPIE Proceedings Vol. 9708:
Photons Plus Ultrasound: Imaging and Sensing 2016
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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