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Proceedings Paper

Critical dosimetry measures and surrogate tools that can facilitate clinical success in PDT (Conference Presentation)
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Paper Abstract

Photodynamic therapy can be a highly complex treatment with more than one parameter to control, or in some cases it is easily implemented with little control other than prescribed drug and light values. The role of measured dosimetry as related to clinical adoption has not been as successful as it could have been, and part of this may be from the conflicting goals of advocating for as many measurements as possible for accurate control, versus companies and clinical adopters advocating for as few measurements as possible, to keep it simple. An organized approach to dosimetry selection is required, which shifts from mechanistic measurements in pre-clinical and early phase I trials, towards just those essential dose limiting measurements and a focus on possible surrogate measures in phase II/III trials. This essential and surrogate approach to dosimetry should help successful adoption of clinical PDT if successful. The examples of essential dosimetry points and surrogate dosimetry tools which might be implemented in phase II and higher trials are discussed for solid tissue PDT with verteporfin and skin lesion treatment with aminolevulinc acid.

Paper Details

Date Published: 26 April 2016
PDF: 1 pages
Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 969405 (26 April 2016); doi: 10.1117/12.2208777
Show Author Affiliations
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
Scott C. Davis, Thayer School of Engineering at Dartmouth (United States)
Stephen C. Kanick, Thayer School of Engineering at Dartmouth (United States)
Edward V. Maytin, Cleveland Clinic Lerner Research Institute (United States)
Stephen P. Pereira, Univ. College London Hospitals (United Kingdom)
Akilan Palanisami, Harvard Medical School (United States)
Tayyaba Hasan, Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 9694:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV
David H. Kessel; Tayyaba Hasan, Editor(s)

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