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Proceedings Paper

Noncontact phase-sensitive dynamic optical coherence elastography at megahertz rate
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Paper Abstract

Dynamic optical coherence elastography (OCE) techniques have shown great promise at quantitatively obtaining the biomechanical properties of tissue. However, the majority of these techniques have required multiple temporal OCT acquisitions (M-B mode) and corresponding excitations, which lead to clinically unfeasible acquisition times and potential tissue damage. Furthermore, the large data sets and extended laser exposures hinder their translation to the clinic, where patient discomfort and safety are critical criteria. In this work we demonstrate noncontact true kilohertz frame-rate dynamic optical coherence elastography by directly imaging a focused air-pulse induced elastic wave with a home-built phase-sensitive OCE system based on a 4X buffered Fourier Domain Mode Locked swept source laser with an A-scan rate of ~1.5 MHz. The elastic wave was imaged at a frame rate of ~7.3 kHz using only a single excitation. In contrast to previous techniques, successive B-scans were acquired over the measurement region (B-M mode) in this work. The feasibility of this method was validated by quantifying the elasticity of tissue-mimicking agar phantoms as well as porcine corneas ex vivo at different intraocular pressures. The results demonstrate that this method can acquire a depth-resolved elastogram in milliseconds. The reduced data set enabled a rapid elasticity assessment, and the ultra-fast acquisition speed allowed for a clinically safe laser exposure to the cornea.

Paper Details

Date Published: 8 March 2016
PDF: 8 pages
Proc. SPIE 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 96970P (8 March 2016); doi: 10.1117/12.2208404
Show Author Affiliations
Manmohan Singh, Univ. of Houston (United States)
Chen Wu, Univ. of Houston (United States)
Chih-Hao Liu, Univ. of Houston (United States)
Jiasong Li, Univ. of Houston (United States)
Alexander Schill, Univ. of Houston (United States)
Achuth Nair, Univ. of Houston (United States)
Yury V. Kistenev, Tomsk State Univ. (Russian Federation)
Kirill V. Larin, Univ. of Houston (United States)
Tomsk State Univ. (Russian Federation)
Baylor College of Medicine (United States)

Published in SPIE Proceedings Vol. 9697:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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