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The influence of cell penetrating peptide branching on cellular uptake of QDs
Author(s): Joyce Breger; James Delehanty; Kimihiro Susumu; George Anderson; Markus Muttenhaler; Philip Dawson; Igor Medintz
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Paper Abstract

Semiconductor quantum dots (QDs) serve as a valuable platform for understating the intricacies of nanoparticle cellular uptake and fate for the development of theranostics. Developing novel internalization peptides that maximize cellular uptake while minimizing the amount of peptide is important to allow space on the nanoparticle for other cargo (e.g. drugs). We have designed a range of branched, dendritic internalization peptides composed of polyarginine (Arg9) branches (1 to 16 repeats) attached a dendritic wedge based on the sequence WP9G2H6. By attaching these branched dendritic peptides to QD’s, we can study the influence of branching on cellular uptake as a function of time, ratio, and degree of branching.

Paper Details

Date Published: 22 April 2016
PDF: 5 pages
Proc. SPIE 9722, Colloidal Nanoparticles for Biomedical Applications XI, 97220R (22 April 2016); doi: 10.1117/12.2207311
Show Author Affiliations
Joyce Breger, U.S. Naval Research Lab. (United States)
James Delehanty, U.S. Naval Research Lab. (United States)
Kimihiro Susumu, U.S. Naval Research Lab. (United States)
George Anderson, U.S. Naval Research Lab. (United States)
Markus Muttenhaler, The Scripps Research Institute (United States)
Philip Dawson, The Scripps Research Institute (United States)
Igor Medintz, U.S. Naval Research Lab. (United States)


Published in SPIE Proceedings Vol. 9722:
Colloidal Nanoparticles for Biomedical Applications XI
Wolfgang J. Parak; Marek Osinski; Xing-Jie Liang, Editor(s)

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