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Proceedings Paper

A novel microfluidic model to mimic the turbid nature and microvasculature of cutaneous tissue for optical imaging experiments
Author(s): Chen Chen; Midhat Ahmed; Florian Klämpfl; Florian Stelzle; Michael Schmidt
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Paper Abstract

To provide clinically relevant insights into the device performance of an optical imaging approach to reconstruct the superficial cutaneous micro-circulation (skin angiography), a phantom device with turbid matrix and perfusable micro-vessels is essential. In this work, we describe a novel microfluidic-based device to mimic the micro-vessels and the turbid nature of the epidermis and dermis. This phantom device contains a hollow assay with a diameter of the channels of 50 μm. The hollow assay includes the geometry of the inlet, the river-like assay, and the outlet, which can be perfused by e.g. meta-hemoglobin solution. This imitates the superficial micro-circulation in the skin. The absorption coefficient μa and the reduced scattering coefficient μs' are adjusted to match those of skin. As an application case, we attempt to reconstruct a 2-D velocity field of the hemoglobin flow in the scattering microfluidic device via the Doppler-mode of an OCT.

Paper Details

Date Published: 9 December 2015
PDF: 9 pages
Proc. SPIE 9792, Biophotonics Japan 2015, 97920J (9 December 2015); doi: 10.1117/12.2203446
Show Author Affiliations
Chen Chen, Friedrich-Alexander-Univ. Erlangen-Nürnberg (Germany)
Midhat Ahmed, Friedrich-Alexander-Univ. Erlangen-Nürnberg (Germany)
Florian Klämpfl, Friedrich-Alexander-Univ. Erlangen-Nürnberg (Germany)
Florian Stelzle, Friedrich-Alexander-Univ. Erlangen-Nürnberg (Germany)
Michael Schmidt, Friedrich-Alexander-Univ. Erlangen-Nürnberg (Germany)

Published in SPIE Proceedings Vol. 9792:
Biophotonics Japan 2015
Takashige Omatsu; Yoshio Hayasaki; Yusuke Ogura; Yasuyuki Ozeki; Seigo Ohno, Editor(s)

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