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Proceedings Paper

Research on imaging, sensing, and characterization of cells at Research Center for Applied Sciences (RCAS), Academia Sinica
Author(s): Hui-Chen Tsai; Chun-Fang Chang; Bi-Chang Chen; Ji-Yen Cheng; Chih-Wei Chu; Hsieh-Cheng Han; Koji Hatanaka; Tung-Han Hsieh; Chau-Hwang Lee; Jung-Hsin Lin; Yi-Chung Tung; Pei-Kuen Wei; Fu-Liang Yang; Din Ping Tsai
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Paper Abstract

Development of imaging, sensing, and characterization of cells at Research Center for Applied Sciences (RCAS) of Academia Sinica in Taiwan is progressing rapidly. The research on advanced lattice light sheet microscopy for temporal visualization of cells in three dimensions at sub-cellular resolution shows novel imaging results. Label-free observation on filopodial dynamics provides a convenient assay on cancer cell motility. The newly-developed software enables us to track the movement of two types of particles through different channels and reconstruct the co-localized tracks. Surface plasmon resonance (SPR) for detecting urinary microRNA for diagnosis of acute kidney injury demonstrates excellent sensitivity. A fully automated and integrated portable reader was constructed as a home-based surveillance system for post-operation hepatocellular carcinoma. New microfluidic cell culture devices for fast and accurate characterizations prove various diagnosis capabilities.

Paper Details

Date Published: 9 December 2015
PDF: 7 pages
Proc. SPIE 9792, Biophotonics Japan 2015, 979212 (9 December 2015); doi: 10.1117/12.2199475
Show Author Affiliations
Hui-Chen Tsai, Academia Sinica (Taiwan)
Chun-Fang Chang, Academia Sinica (Taiwan)
Bi-Chang Chen, Academia Sinica (Taiwan)
Ji-Yen Cheng, Academia Sinica (Taiwan)
Chih-Wei Chu, Academia Sinica (Taiwan)
Hsieh-Cheng Han, Academia Sinica (Taiwan)
Koji Hatanaka, Academia Sinica (Taiwan)
Tung-Han Hsieh, Academia Sinica (Taiwan)
Chau-Hwang Lee, Academia Sinica (Taiwan)
Jung-Hsin Lin, Academia Sinica (Taiwan)
Yi-Chung Tung, Academia Sinica (Taiwan)
Pei-Kuen Wei, Academia Sinica (Taiwan)
Fu-Liang Yang, Academia Sinica (Taiwan)
Din Ping Tsai, Academia Sinica (Taiwan)

Published in SPIE Proceedings Vol. 9792:
Biophotonics Japan 2015
Takashige Omatsu; Yoshio Hayasaki; Yusuke Ogura; Yasuyuki Ozeki; Seigo Ohno, Editor(s)

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