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Proceedings Paper

Femtosecond laser subsurface scleral treatment in cadaver human sclera and evaluation using two-photon and confocal microscopy
Author(s): Hui Sun; Zhongwei Fan; Ying Yan; Fuqiang Lian; Ron Kurtz; Tibor Juhasz
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Paper Abstract

Glaucoma is the second-leading cause of blindness worldwide and is often associated with elevated intraocular pressure (IOP). Partial-thickness drainage channels can be created with femtosecond laser in the translucent sclera for the potential treatment of glaucoma. We demonstrate the creation of partial-thickness subsurface drainage channels with the femtosecond laser in the cadaver human eyeballs and describe the application of two-photon microscopy and confocal microscopy for noninvasive imaging of the femtosecond laser created partial-thickness scleral channels in cadaver human eyes. A femtosecond laser operating at a wavelength of 1700 nm was scanned along a rectangular raster pattern to create the partial thickness subsurface drainage channels in the sclera of cadaver human eyes. Analysis of the dimensions and location of these channels is important in understanding their effects. We describe the application of two-photon microscopy and confocal microscopy for noninvasive imaging of the femtosecond laser created partial-thickness scleral channels in cadaver human eyes. High-resolution images, hundreds of microns deep in the sclera, were obtained to allow determination of the shape and dimension of such partial thickness subsurface scleral channels. Our studies suggest that the confocal and two-photon microscopy can be used to investigate femtosecond-laser created partial-thickness drainage channels in the sclera of cadaver human eyes.

Paper Details

Date Published: 7 March 2016
PDF: 11 pages
Proc. SPIE 9706, Optical Interactions with Tissue and Cells XXVII, 97060N (7 March 2016); doi: 10.1117/12.2197912
Show Author Affiliations
Hui Sun, Academy of Opto-Electronics (China)
Zhongwei Fan, Academy of Opto-Electronics (China)
Ying Yan, Academy of Opto-Electronics (China)
Fuqiang Lian, Academy of Opto-Electronics (China)
Ron Kurtz, Univ. of California at Irvine (United States)
Tibor Juhasz, Univ. of California at Irvine (United States)


Published in SPIE Proceedings Vol. 9706:
Optical Interactions with Tissue and Cells XXVII
E. Duco Jansen, Editor(s)

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