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Proceedings Paper

Quantum dot-tetrapyrrole complexes as photodynamic therapy agents
Author(s): Irina Martynenko; Anastasia Visheratina; Vera Kuznetsova; Anna Orlova; Vladimir Maslov; Anatoly Fedorov; Alexander Baranov
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Paper Abstract

Photophysical properties of complexes of semiconductor quantum dots with conventional photosensitizers for photodynamic therapy (tetrapyrroles) were investigated. A luminescent study of complexes in aqueous solutions was performed using spectral- and time-resolved luminescence spectroscopy. It was found that increasing the photosensitizer relative concentration in complexes resulted in sharp drop of the nonradiative energy transfer efficiency and the quantum yield of the photosensitizer photoluminescence. This fact indicates that additional channels of nonradiative energy dissipation may take place in the complexes. Using complexes of Al(OH)-sulphophthalocyanine with CdSe/ZnS quantum dots in the aqueous solution as an typical example, we have demonstrated that new channels of the energy dissipation may arise due to aggregation of the photosensitizer molecules upon formation of the complexes with quantum dots. We also demonstrated that use of methods of complex formation preventing aggregation of photosensitizers allows to conserve the high energy transfer efficiency and quantum yield of the acceptor photoluminescence in complexes in wide range of the photosensitizer concentrations. We believe that our study allows obtaining new information about the physical mechanisms of nonradiative energy transfer in quantum dots-tetrapyrrole complexes perspective for photodynamic therapy.

Paper Details

Date Published: 15 July 2015
PDF: 8 pages
Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95372E (15 July 2015); doi: 10.1117/12.2197859
Show Author Affiliations
Irina Martynenko, ITMO Univ. (Russian Federation)
Anastasia Visheratina, ITMO Univ. (Russian Federation)
Vera Kuznetsova, ITMO Univ. (Russian Federation)
Anna Orlova, ITMO Univ. (Russian Federation)
Vladimir Maslov, ITMO Univ. (Russian Federation)
Anatoly Fedorov, ITMO Univ. (Russian Federation)
Alexander Baranov, ITMO Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 9537:
Clinical and Biomedical Spectroscopy and Imaging IV
J. Quincy Brown; Volker Deckert, Editor(s)

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