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Proceedings Paper

Lab-on-Fiber biosensing for cancer biomarker detection
Author(s): A. Ricciardi; R. Severino; G. Quero; B. Carotenuto; M. Consales; A. Crescitelli; E. Esposito; M. Ruvo; A. Sandomenico; A. Borriello; M. Giordano; L. Sansone; Carmine Granata; A. Cutolo; A. Cusano
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Paper Abstract

This work deals with a novel Lab-on-Fiber biosensor able to detect in real time thyroid carcinomas biomarkers. The device is based on a gold nanostructure supporting localized surface plasmon resonances (LSPR) directly fabricated on the fiber tip by means of electron beam lithography and lift-off process. Following a suitable chemical and biological functionalization of the sensing area, human Thyroglobulin has been detected at nanomolar concentrations. Also, compatibility with full baseline restoration, achieved through biomarkers/bioreceptors dissociation, has been demonstrated.

Paper Details

Date Published: 28 September 2015
PDF: 4 pages
Proc. SPIE 9634, 24th International Conference on Optical Fibre Sensors, 963423 (28 September 2015); doi: 10.1117/12.2194943
Show Author Affiliations
A. Ricciardi, Univ. degli Studi del Sannio (Italy)
R. Severino, Univ. degli Studi del Sannio (Italy)
G. Quero, Univ. degli Studi del Sannio (Italy)
B. Carotenuto, Univ. degli Studi del Sannio (Italy)
M. Consales, Univ. degli Studi del Sannio (Italy)
A. Crescitelli, Istituto per la Microelettronica e Microsistemi, CNR (Italy)
E. Esposito, Istituto per la Microelettronica e Microsistemi, CNR (Italy)
M. Ruvo, Istituto di Biostrutture e Bioimmagini, CNR (Italy)
A. Sandomenico, Istituto di Biostrutture e Bioimmagini, CNR (Italy)
A. Borriello, Istituto per i Polimeri Compositi e Biomateriali, CNR (Italy)
M. Giordano, Istituto per i Polimeri Compositi e Biomateriali, CNR (Italy)
L. Sansone, Istituto per i Polimeri Compositi e Biomateriali, CNR (Italy)
Carmine Granata, Istituto di Cibernetica Eduardo Caianiello, CNR (Italy)
A. Cutolo, Univ. degli Studi del Sannio (Italy)
A. Cusano, Univ. degli Studi del Sannio (Italy)


Published in SPIE Proceedings Vol. 9634:
24th International Conference on Optical Fibre Sensors
Hypolito José Kalinowski; José Luís Fabris; Wojtek J. Bock, Editor(s)

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