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Proceedings Paper

Real time monitoring of Pb2+-induced formation of G-quadruplex DNA with LPFG sensor
Author(s): Z. Bagheri; H. Latifi; B. Ranjbar; M. I. Zibaii; E. Behroodi
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Paper Abstract

In this paper the potential of real time monitoring of AS1411 Guanine-quadruplex folding by using long period fiber grating (LPFG) biosensor was described. AS1411 ss-DNA folds into parallel bimolecular quadruplex in solution containing metal ions. While immobilized AS1411 folds, molecular crowding of sensing area will increase and cause change the refractive index (RI) around the sensor. In addition RI change is absolutely dependent on G-quadruplex factor concentration.

Paper Details

Date Published: 28 September 2015
PDF: 4 pages
Proc. SPIE 9634, 24th International Conference on Optical Fibre Sensors, 96344E (28 September 2015); doi: 10.1117/12.2193767
Show Author Affiliations
Z. Bagheri, Tarbiat Modares Univ. (Iran, Islamic Republic of)
H. Latifi, Shahid Beheshti Univ. (Iran, Islamic Republic of)
B. Ranjbar, Tarbiat Modares Univ. (Iran, Islamic Republic of)
M. I. Zibaii, Shahid Beheshti Univ. (Iran, Islamic Republic of)
E. Behroodi, Shahid Beheshti Univ. (Iran, Islamic Republic of)


Published in SPIE Proceedings Vol. 9634:
24th International Conference on Optical Fibre Sensors
Hypolito José Kalinowski; José Luís Fabris; Wojtek J. Bock, Editor(s)

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