Share Email Print
cover

Proceedings Paper

In-situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers under static and dynamic conditions
Author(s): Fei Tian; Jouha Min; Jiri Kanka; Paula T. Hammond; Henry Du
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

The release profiles of gentamicin sulfate (GS) from [chitosan (CHI)/poly(acrylic acid) (PAA)/GS/PAA]n polyelectrolyte multilayers were investigated in situ using an innovative lab-on-fiber (LOF) optofluidic platform that mimics physiologically relevant fluid flow in a microenvironment. The LOF was constructed by enclosing in a flow-enabled and optically coupled glass capillary a long-period fiber grating both as a substrate for LbL growth of [CHI/PAA/GS/PAA]n and a measurement probe for GS release. We show that the LOF is very robust in monitoring the construction of the [CHI/PAA/GS/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release with high sensitivity. The release processes in the LOF under static and a range of dynamic conditions are evaluated, showing a faster release under dynamic condition than that under static condition due to the varying circumstance of GS concentration gradient and the effect of flow-induced shear at the medium-multilayer interface. The LOF platform has the potential to be a powerful test bed to facilitate the design and evaluation of drug-eluting polyelectrolyte thin films for their clinical insertion as part of patient care strategy.

Paper Details

Date Published: 3 June 2015
PDF: 9 pages
Proc. SPIE 9480, Fiber Optic Sensors and Applications XII, 948005 (3 June 2015); doi: 10.1117/12.2191683
Show Author Affiliations
Fei Tian, Stevens Institute of Technology (United States)
Jouha Min, Massachusetts Institute of Technology (United States)
David H. Koch Institute for Integrative Cancer Research (United States)
Jiri Kanka, Institute of Photonics and Electronics of the ASCR, v.v.i. (Czech Republic)
Paula T. Hammond, Massachusetts Institute of Technology (United States)
David H. Koch Institute for Integrative Cancer Research (United States)
Henry Du, Stevens Institute of Technology (United States)


Published in SPIE Proceedings Vol. 9480:
Fiber Optic Sensors and Applications XII
Gary Pickrell; Eric Udd; Henry H. Du, Editor(s)

© SPIE. Terms of Use
Back to Top