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Proceedings Paper

Anticancer photodynamic therapy based on the use of a microsystem
Author(s): E. Jastrzebska; N. Bulka; K. Zukowski; M. Chudy; Z. Brzozka; A. Dybko
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Paper Abstract

The paper presents the evaluation of photodynamic therapy (PDT) procedures with an application of a microsystem. Two cell lines were used in the experiments, i.e. human lung carcinoma - A549 and normal human fetal lung fibroblast MRC5. Mono-, coculture and mixed cultures were performed in a microsystem at the same time. The microsystem consisted of a concentration gradient generator (CGG) which generates different concentrations of a photosensitizer, and a set of microchambers for cells. The microchambers were linked by microchannels of various length in order to allow cells migration and in this way cocultures were created. Transparent materials were used for the chip manufacture, i.e. glass and poly(dimethylsiloxane). A high power LED was used to test photodynamic therapy effectiveness in the microsystem.

Paper Details

Date Published: 17 July 2015
PDF: 4 pages
Proc. SPIE 9540, Novel Biophotonics Techniques and Applications III, 95400X (17 July 2015); doi: 10.1117/12.2191503
Show Author Affiliations
E. Jastrzebska, Warsaw Univ. of Technology (Poland)
N. Bulka, Warsaw Univ. of Technology (Poland)
K. Zukowski, Warsaw Univ. of Technology (Poland)
M. Chudy, Warsaw Univ. of Technology (Poland)
Z. Brzozka, Warsaw Univ. of Technology (Poland)
A. Dybko, Warsaw Univ. of Technology (Poland)

Published in SPIE Proceedings Vol. 9540:
Novel Biophotonics Techniques and Applications III
Arjen Amelink; I. Alex Vitkin, Editor(s)

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