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Proceedings Paper

Stability studies on Promethazine unexposed and exposed to UV laser radiation
Author(s): Adriana Smarandache; Agota Simon; Tatiana Tozar; Viorel Nastasa; Mihail Lucian Pascu
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Paper Abstract

As a phenothiazine derivative, Promethazine may undergo structural modifications when it is exposed to light. This process consists in the degradation of the initial compound and in the generation of new photoproducts with possible anti-infectious qualities. Stability studies are necessary in order to establish the proper use of drug solutions in different applications. At the same time, these investigations are important in the context of the generation of side-products induced by environmental conditions that bring new benefits to the compound.

This study reports the stability of Promethazine aqueous solutions, based on their absorption spectra acquired before and after Nd:YAG laser irradiation sessions or under different temperature and illuminating storage conditions. Samples of Promethazine solutions in ultrapure water, at a concentration range between 10-6 M – 10-2 M, were kept in dark at 22°C, and 4°C as well as at 22°C in ambient light up to a time interval of three months. Absorption spectra were recorded periodically in order to determine any changes of the optical properties. Also, solutions of 20 mg/mL were exposed for different time intervals to laser radiation emitted at 266 nm by the Nd:YAG laser. The stability of the optical properties of irradiated Promethazine solutions for 4 h was investigated up to two months.

The laser irradiated samples show similar but more rapid and intense changes compared to solutions exposed to ambient light, suggesting molecular modifications that could be due to the production of more polar phenothiazine derivatives.

Paper Details

Date Published: 10 September 2015
PDF: 9 pages
Proc. SPIE 9549, Physical Chemistry of Interfaces and Nanomaterials XIV, 954916 (10 September 2015); doi: 10.1117/12.2189289
Show Author Affiliations
Adriana Smarandache, National Institute for Laser, Plasma and Radiation Physics (Romania)
Univ. of Bucharest (Romania)
Agota Simon, National Institute for Laser, Plasma and Radiation Physics (Romania)
Univ. of Bucharest (Romania)
Tatiana Tozar, National Institute for Laser, Plasma and Radiation Physics (Romania)
Univ. of Bucharest (Romania)
Viorel Nastasa, National Institute for Laser, Plasma and Radiation Physics (Romania)
Univ. of Bucharest (Romania)
Mihail Lucian Pascu, National Institute for Laser, Plasma and Radiation Physics (Romania)
Univ. of Bucharest (Romania)


Published in SPIE Proceedings Vol. 9549:
Physical Chemistry of Interfaces and Nanomaterials XIV
Sophia C. Hayes; Eric R. Bittner, Editor(s)

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