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Proceedings Paper

Real-time protein aggregation monitoring based on a simultaneous light scattering investigation and a Bloch surface wave-based approach
Author(s): Sara Santi; Elsie Barakat; Reinhard Neier; Hans Peter Herzig
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Paper Abstract

We present a study of the dynamics of protein aggregation using a Bloch surface wave (BSW) label-free sensing scheme. In a previous work, we demonstrated the ability to detect the early dynamic events of fibrillogenesis of amyloid betapeptides (Aβ), linked to Alzheimer’s Disease. Here, we demonstrate the efficacy of the BSW sensor by describing a simultaneous light scattering measurement, with the purpose of real-time monitoring the size change of the Aβ aggregates, throughout fibrillization.

Paper Details

Date Published: 21 August 2015
PDF: 3 pages
Proc. SPIE 9550, Biosensing and Nanomedicine VIII, 95500V (21 August 2015); doi: 10.1117/12.2188595
Show Author Affiliations
Sara Santi, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Univ. de Neuchâtel (Switzerland)
Elsie Barakat, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Reinhard Neier, Univ. de Neuchâtel (Switzerland)
Hans Peter Herzig, Ecole Polytechnique Fédérale de Lausanne (Switzerland)

Published in SPIE Proceedings Vol. 9550:
Biosensing and Nanomedicine VIII
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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