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Proceedings Paper

Investigation of pharmaceutical drugs and caffeine-containing foods using Fourier and terahertz time-domain spectroscopy
Author(s): Mindaugas Karaliūnas; Rimvydas Venckevičius; Irmantas Kašalynas; Uroš Puc; Andreja Abina; Anton Jeglič; Aleksander Zidanšek; Gintaras Valušis
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Paper Abstract

Several pharmaceutical drugs, such as alprazolam, ibuprofen, acetaminophen, activated carbon and others, and caffeine-containing foods were tested using terahertz (THz) time domain spectroscopy in the range from 0.3 to 2 THz. The dry powder of pharmaceutical drugs was mixed with HDPE and pressed into the pellets using hydraulic press. The coffee grounds were also pressed into the pellets after ball-milling and mixing with HDPE. The caffeine containing liquid foods were dried out on the paper strips of various stacking. Experiments allow one to determine characteristic spectral signatures of the investigated substances within THz range caused by active pharmaceutical ingredients, like in the case of caffeine, as well as supporting pharmaceutical ingredients. Spectroscopic THz imaging approach is considered as a possible option to identify packaged pharmaceutical drugs. The caffeine spectral features in the tested caffeine containing foods are difficult to observed due to the low caffeine concentration and complex caffeine chemical surrounding.

Paper Details

Date Published: 31 August 2015
PDF: 8 pages
Proc. SPIE 9585, Terahertz Emitters, Receivers, and Applications VI, 95850U (31 August 2015); doi: 10.1117/12.2188015
Show Author Affiliations
Mindaugas Karaliūnas, Ctr. for Physical Sciences and Technology (Lithuania)
Rimvydas Venckevičius, Ctr. for Physical Sciences and Technology (Lithuania)
Irmantas Kašalynas, Ctr. for Physical Sciences and Technology (Lithuania)
Uroš Puc, Jožef Stefan International Postgraduate School (Slovenia)
Andreja Abina, Jožef Stefan International Postgraduate School (Slovenia)
Anton Jeglič, Jožef Stefan International Postgraduate School (Slovenia)
Aleksander Zidanšek, Jožef Stefan International Postgraduate School (Slovenia)
Gintaras Valušis, Ctr. for Physical Sciences and Technology (Lithuania)


Published in SPIE Proceedings Vol. 9585:
Terahertz Emitters, Receivers, and Applications VI
Manijeh Razeghi; Alexei N. Baranov; John M. Zavada; Dimitris Pavlidis, Editor(s)

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