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Proceedings Paper

A creatinine biosensor based on admittance measurement
Author(s): Congo Tak-Shing Ching; Tai-Ping Sun; Deng-Yun Jheng; Hou-Wei Tsai; Hsiu-Li Shieh
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Paper Abstract

Regular check of blood creatinine level is very important as it is a measurement of renal function. Therefore, the objective of this study is to develop a simple and reliable creatinine biosensor based on admittance measurement for precise determination of creatinine. The creatinine biosensor was fabricated with creatinine deiminase immobilized on screen-printed carbon electrodes. Admittance measurement at a specific frequency ranges (22.80 - 84.71 Hz) showed that the biosensor has an excellent linear (r2 > 0.95) response range (50 - 250 uM), which covers the normal physiological and pathological ranges of blood creatinine levels. Intraclass correlation coefficient (ICC) showed that the biosensor has excellent reliability and validity (ICC = 0.98). In conclusion, a simple and reliable creatinine biosensor was developed and it is capable of precisely determining blood creatinine levels in both the normal physiological and pathological ranges.

Paper Details

Date Published: 21 August 2015
PDF: 4 pages
Proc. SPIE 9550, Biosensing and Nanomedicine VIII, 95500N (21 August 2015); doi: 10.1117/12.2187305
Show Author Affiliations
Congo Tak-Shing Ching, National Chi Nan Univ. (Taiwan)
Tai-Ping Sun, National Chi Nan Univ. (Taiwan)
Nan Kai Univ. of Technology (Taiwan)
Deng-Yun Jheng, National Chi Nan Univ. (Taiwan)
Hou-Wei Tsai, National Chi Nan Univ. (Taiwan)
Hsiu-Li Shieh, National Chi Nan Univ. (Taiwan)


Published in SPIE Proceedings Vol. 9550:
Biosensing and Nanomedicine VIII
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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