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Proceedings Paper

Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation
Author(s): Alessandro D. Mota; André M. Cestari; André O. de Oliveira; Anselmo G. Oliveira; Cristina H. B. Terruggi; Giuliano Rossi; Jarbas C. Castro ; João P. B. Ligabô; Tiago A. Ortega; Tiago Rosa
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Paper Abstract

This work presents an innovative cross-linking procedure to keratoconus treatment, a corneal disease. It includes the development of an ultraviolet controlled emission portable device based on LED source and a new formulation of a photosensitive drug called riboflavin. Thus new formulation improves drug administration by its transepithelial property. The UV reaction with riboflavin in corneal tissue leads to a modification of corneal collagen fibers, turning them more rigid and dense, and consequently restraining the advance of the disease. We present the control procedures to maintain UV output power stable up to 45mw/cm2, the optical architecture that leads to a homogeneous UV spot and the new formulation of Riboflavin.

Paper Details

Date Published: 8 September 2015
PDF: 13 pages
Proc. SPIE 9571, Fourteenth International Conference on Solid State Lighting and LED-based Illumination Systems, 95710X (8 September 2015); doi: 10.1117/12.2187265
Show Author Affiliations
Alessandro D. Mota, Opto Eletrônica S.A. (Brazil)
André M. Cestari, Opto Eletrônica S.A. (Brazil)
André O. de Oliveira, Opto Eletrônica S.A. (Brazil)
Univ. de São Paulo (Brazil)
Anselmo G. Oliveira, Univ. Estadual Paulista (Brazil)
Cristina H. B. Terruggi, Univ. Estadual Paulista (Brazil)
Giuliano Rossi, Opto Eletrônica S.A. (Brazil)
Jarbas C. Castro , Univ. de São Paulo (Brazil)
João P. B. Ligabô, Opto Eletrônica S.A. (Brazil)
Tiago A. Ortega, Opto Eletrônica S.A. (Brazil)
Tiago Rosa, Opto Eletrônica S.A. (Brazil)

Published in SPIE Proceedings Vol. 9571:
Fourteenth International Conference on Solid State Lighting and LED-based Illumination Systems
Matthew H. Kane; Jianzhong Jiao; Nikolaus Dietz; Jian-Jang Huang, Editor(s)

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