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Proceedings Paper

Manipulating lipid membrane architecture by liquid crystal-analog curvature elasticity (Presentation Recording)
Author(s): Sin-Doo Lee

Paper Abstract

Soft matters such as liquid crystals and biological molecules exhibit a variety of interesting physical phenomena as well as new applications. Recently, in mimicking biological systems that have the ability to sense, regulate, grow, react, and regenerate in a highly responsive and self-adaptive manner, the significance of the liquid crystal order in living organisms, for example, a biological membrane possessing the lamellar order, is widely recognized from the viewpoints of physics and chemistry of interfaces and membrane biophysics. Lipid bilayers, resembling cell membranes, provide primary functions for the transport of biological components of ions and molecules in various cellular activities, including vesicle budding and membrane fusion, through lateral organization of the membrane components such as proteins. In this lecture, I will describe how the liquid crystal-analog curvature elasticity of a lipid bilayer plays a critical role in developing a new platform for understanding diverse biological functions at a cellular level. The key concept is to manipulate the local curvature at an interface between a solid substrate and a model membrane. Two representative examples will be demonstrated: one of them is the topographic control of lipid rafts in a combinatorial array where the ligand-receptor binding event occurs and the other concerns the reconstitution of a ring-type lipid raft in bud-mimicking architecture within the framework of the curvature elasticity.

Paper Details

Date Published: 5 October 2015
PDF: 1 pages
Proc. SPIE 9565, Liquid Crystals XIX, 95650B (5 October 2015); doi: 10.1117/12.2186919
Show Author Affiliations
Sin-Doo Lee, Seoul National Univ. (Korea, Republic of)


Published in SPIE Proceedings Vol. 9565:
Liquid Crystals XIX
Iam Choon Khoo, Editor(s)

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