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Proceedings Paper

Wafer-scale aluminum plasmonics for fluorescence based biodetection
Author(s): Arash Farhang; Matthew C. George; Brent Williamson; Mike Black; Ted Wangensteen; James Fraser; Rumyana Petrova; Kent Prestgard
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Paper Abstract

Moxtek has leveraged existing capabilities in wafer-scale patterning of sub-wavelength wire grid polarizers into the fabrication of 1D and 2D periodic aluminum plasmonic structures. This work will discuss progress in 200 mm diameter wafer-scale fabrication, with detailed emphasis within the realm of microarray based fluorescence detection. Aluminum nanohole arrays in a hexagonal lattice are first numerically investigated. The nanohole array geometry and periodicity are specifically tuned to coincide both with the excitation of the fluorophore Cy3, and to provide a high field enhancement within the nanoholes where labeled biomolecules are captured. This is accomplished through numerical modelling, nanofabrication, SEM imaging, and optical characterization. A 200mm diameter wafer, patterned with the optically optimized nanohole array, is cut into standard 1x3 inch microscope slide pieces and then subsequently printed with various antigens at 9 different concentrations. A sandwich bioassay is then carried out, using the corresponding conjugate antibodies in order to demonstrate specificity. The nanohole array exhibit a 3-4 times total fluorescence enhancement of Cy3, when compared to a leading commercial microarray glass slide.

Paper Details

Date Published: 21 August 2015
Proc. SPIE 9550, Biosensing and Nanomedicine VIII, 95500U (21 August 2015); doi: 10.1117/12.2186871
Show Author Affiliations
Arash Farhang, MOXTEK, Inc. (United States)
Matthew C. George, MOXTEK, Inc. (United States)
Brent Williamson, MOXTEK, Inc. (United States)
Mike Black, MOXTEK, Inc. (United States)
Ted Wangensteen, MOXTEK, Inc. (United States)
James Fraser, MOXTEK, Inc. (United States)
Rumyana Petrova, MOXTEK, Inc. (United States)
Kent Prestgard, MOXTEK, Inc. (United States)

Published in SPIE Proceedings Vol. 9550:
Biosensing and Nanomedicine VIII
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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