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Proceedings Paper

Small-area fiber-coupled scintillation camera for imaging beta-ray distributions intraoperatively
Author(s): Lawrence R. MacDonald; Martin P. Tornai; Craig S. Levin; J. Park; Muzaffer Atac; David B. Cline; Eric G. Hoffman
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Paper Abstract

A small area, imaging, scintillation probe is being developed for locating small amounts of radio-labeled malignant tissue during surgery. Preliminary in brain surgery, avoiding the removal of excess tissue is a priority. It is possible to locate the main body of a brain tumor both before and during surgery, but once the bulk of the tumor is excised the identification of residual malignant tissue is difficult. A probe that covers an area of 1-2 cm2 with an intrinsic resolution of 1-2 mm could locate small tumor masses that pose a threat of recurrence of the disease, and prevent removal of healthy tissue. A pre-operative injection of tumor seeking, beta emitting radiopharmaceutical (e.g. 18fluorodeoxyuridine-FDUR-) will label the tumor. The limited range of beta-rays ensures proximity upon successful detection. Plastic scintillators are used for beta detection, and visible light photon counters (VLPCs) detect the scintillation light. For maneuverability in and around the surgical cavity, the scintillators are coupled to the VLPCs via 2 m of optical fiber. An imaging device can cover the tissue bed in a time compatible with surgery, as opposed to a single element detector on the order of 1-2 mm in size with comparable resolution. An imager also distinguishes high background rates (such as from annihilation gammas in FDUR) and concentrations of activity.

Paper Details

Date Published: 8 September 1995
PDF: 10 pages
Proc. SPIE 2551, Photoelectronic Detectors, Cameras, and Systems, (8 September 1995); doi: 10.1117/12.218645
Show Author Affiliations
Lawrence R. MacDonald, Univ. of California/Los Angeles (United States)
Martin P. Tornai, Univ. of California/Los Angeles (United States)
Craig S. Levin, Univ. of California/Los Angeles (United States)
J. Park, Univ. of California/Los Angeles (United States)
Muzaffer Atac, Univ. of California/Los Angeles (United States)
David B. Cline, Univ. of California/Los Angeles (United States)
Eric G. Hoffman, Univ. of California/Los Angeles (United States)


Published in SPIE Proceedings Vol. 2551:
Photoelectronic Detectors, Cameras, and Systems
C. Bruce Johnson; Ervin J. Fenyves, Editor(s)

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